Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5117664..5118331 Replicon chromosome
Accession NZ_CP060002
Organism Xanthomonas citri pv. citri strain SN3-3

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag HZS91_RS21825 Protein ID WP_005916679.1
Coordinates 5117915..5118331 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag HZS91_RS21820 Protein ID WP_005916676.1
Coordinates 5117664..5117918 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS91_RS21795 (HZS91_04632) 5113826..5114005 + 180 WP_011052886.1 RNA 2'-phosphotransferase -
HZS91_RS21800 (HZS91_04633) 5114162..5115427 + 1266 WP_015463799.1 phospholipase D-like domain-containing protein -
HZS91_RS21805 (HZS91_04634) 5115453..5115980 - 528 WP_005916668.1 hypothetical protein -
HZS91_RS21810 (HZS91_04635) 5116219..5116425 + 207 WP_003489327.1 hypothetical protein -
HZS91_RS21815 (HZS91_04636) 5116412..5117518 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZS91_RS21820 (HZS91_04637) 5117664..5117918 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
HZS91_RS21825 (HZS91_04638) 5117915..5118331 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
HZS91_RS21830 (HZS91_04639) 5118453..5118725 - 273 WP_129545227.1 hypothetical protein -
HZS91_RS21835 (HZS91_04640) 5118784..5118996 - 213 WP_015472901.1 hypothetical protein -
HZS91_RS21840 (HZS91_04641) 5119253..5120872 + 1620 WP_015463800.1 alpha/beta hydrolase-fold protein -
HZS91_RS21845 (HZS91_04642) 5120976..5121374 - 399 WP_004429277.1 DUF2384 domain-containing protein -
HZS91_RS21850 (HZS91_04643) 5121690..5122121 + 432 WP_005922907.1 hypothetical protein -
HZS91_RS21855 5122150..5122380 - 231 WP_223293191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T169679 WP_005916679.1 NZ_CP060002:5117915-5118331 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T169679 NZ_CP076654:2726898-2727005 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT169679 WP_005916676.1 NZ_CP060002:5117664-5117918 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT169679 NZ_CP076654:c2726845-2726784 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References