Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4719769..4720130 Replicon chromosome
Accession NZ_CP060002
Organism Xanthomonas citri pv. citri strain SN3-3

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag HZS91_RS20260 Protein ID WP_005914328.1
Coordinates 4719769..4719903 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag HZS91_RS20265 Protein ID WP_003486606.1
Coordinates 4719978..4720130 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS91_RS20240 (HZS91_04295) 4714907..4716598 - 1692 WP_015471463.1 M28 family metallopeptidase -
HZS91_RS20245 (HZS91_04296) 4716790..4717734 - 945 WP_015463704.1 MBL fold metallo-hydrolase -
HZS91_RS20250 (HZS91_04297) 4717863..4719152 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
HZS91_RS20255 (HZS91_04298) 4719333..4719542 - 210 WP_003486601.1 CsbD family protein -
HZS91_RS20260 (HZS91_04299) 4719769..4719903 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
HZS91_RS20265 (HZS91_04300) 4719978..4720130 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
HZS91_RS20270 (HZS91_04301) 4720237..4721160 - 924 WP_005927745.1 arginase -
HZS91_RS20275 (HZS91_04302) 4721481..4721933 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
HZS91_RS20280 (HZS91_04303) 4721997..4722356 + 360 WP_003486613.1 hypothetical protein -
HZS91_RS20285 (HZS91_04304) 4722453..4723370 + 918 WP_011052673.1 hypothetical protein -
HZS91_RS20290 (HZS91_04305) 4723367..4723909 + 543 WP_003486615.1 GTPase -
HZS91_RS20295 (HZS91_04307) 4724347..4725030 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T169678 WP_005914328.1 NZ_CP060002:c4719903-4719769 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T169678 NZ_CP076654:2726362-2726469 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT169678 WP_003486606.1 NZ_CP060002:c4720130-4719978 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT169678 NZ_CP076654:c2726315-2726249 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References