Detailed information of TA system TA169676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2618786..2619419
• Replicon: chromosome
• Accession: NZ_CP060002
• Organism: Xanthomonas citri pv. citri strain SN3-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HZS91_RS11365
• Protein ID: WP_015463212.1
• Coordinates: 2618786..2619199 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: HZS91_RS11370
• Protein ID: WP_015463213.1
• Coordinates: 2619186..2619419 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS91_RS11350 (HZS91_02393)	2614550..2616658	+	2109	WP_191105149.1	TonB-dependent siderophore receptor	-
HZS91_RS11355 (HZS91_02394)	2616867..2618381	+	1515	WP_219875322.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
HZS91_RS11360 (HZS91_02395)	2618397..2618759	-	363	WP_015463211.1	DUF3742 family protein	-
HZS91_RS11365 (HZS91_02396)	2618786..2619199	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
HZS91_RS11370 (HZS91_02397)	2619186..2619419	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HZS91_RS11375 (HZS91_02398)	2619701..2620708	+	1008	WP_015463214.1	DUF4917 family protein	-
HZS91_RS11380 (HZS91_02399)	2620841..2621296	-	456	WP_015463215.1	hypothetical protein	-
HZS91_RS11385 (HZS91_02400)	2621691..2622266	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
HZS91_RS11390 (HZS91_02401)	2622247..2623296	+	1050	WP_011051401.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T169676 WP_015463212.1 NZ_CP060002:c2619199-2618786 [Xanthomonas citri pv. citri]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T169676 NZ_CP076654:2126392-2126495 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT169676 WP_015463213.1 NZ_CP060002:c2619419-2619186 [Xanthomonas citri pv. citri]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT169676 NZ_CP076654:c2126533-2126262 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: M4TWF0