Detailed information of TA system TA169664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2548837..2549470
• Replicon: chromosome
• Accession: NZ_CP059999
• Organism: Xanthomonas citri pv. citri strain B2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HZS92_RS11130
• Protein ID: WP_015463212.1
• Coordinates: 2548837..2549250 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: HZS92_RS11135
• Protein ID: WP_015463213.1
• Coordinates: 2549237..2549470 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS92_RS11115 (HZS92_02339)	2544775..2546709	+	1935	WP_230598900.1	TonB-dependent siderophore receptor	-
HZS92_RS11120 (HZS92_02340)	2546918..2548432	+	1515	WP_015463210.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
HZS92_RS11125 (HZS92_02341)	2548448..2548810	-	363	WP_015463211.1	DUF3742 family protein	-
HZS92_RS11130 (HZS92_02342)	2548837..2549250	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
HZS92_RS11135 (HZS92_02343)	2549237..2549470	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HZS92_RS11140 (HZS92_02344)	2549728..2550759	+	1032	WP_040107627.1	DUF4917 family protein	-
HZS92_RS11145 (HZS92_02345)	2550892..2551347	-	456	WP_015463215.1	hypothetical protein	-
HZS92_RS11150 (HZS92_02346)	2551742..2552317	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
HZS92_RS11155 (HZS92_02347)	2552298..2553347	+	1050	WP_011051401.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T169664 WP_015463212.1 NZ_CP059999:c2549250-2548837 [Xanthomonas citri pv. citri]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T169664 NZ_CP076653:5037767-5038507 [Bacillus sp. NP247]
TTGACGATCTCTAACATTCGAATCGGTTTATTTATTCTAGTAATCGCCTTTGTAGTTCTTGTTTTCTTTTATTGGAAAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACTTGGTATGGTTTGTTTATAATATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCGATGGTAATTTTCGTTGATATTGCA
TTTATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAGCAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTGTTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTAGTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAACAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAACTGTGAGTG
ATGTCTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT169664 WP_015463213.1 NZ_CP059999:c2549470-2549237 [Xanthomonas citri pv. citri]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT169664 NZ_CP076653:5038620-5038745 [Bacillus sp. NP247]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: M4TWF0