Detailed information of TA system TA169663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 99414..99958
• Replicon: chromosome
• Accession: NZ_CP059999
• Organism: Xanthomonas citri pv. citri strain B2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8FI26
• Locus tag: HZS92_RS00430
• Protein ID: WP_003487886.1
• Coordinates: 99659..99958 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: HZS92_RS00425
• Protein ID: WP_003487884.1
• Coordinates: 99414..99671 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS92_RS00410 (HZS92_00086)	94533..96014	-	1482	WP_015462698.1	ribonuclease H-like domain-containing protein	-
HZS92_RS00415 (HZS92_00087)	96011..98506	-	2496	WP_015462699.1	DEAD/DEAH box helicase	-
HZS92_RS00420 (HZS92_00088)	98684..99346	+	663	WP_005912558.1	hemolysin III family protein	-
HZS92_RS00425 (HZS92_00089)	99414..99671	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HZS92_RS00430 (HZS92_00090)	99659..99958	+	300	WP_003487886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZS92_RS00440 (HZS92_00092)	100138..101037	-	900	WP_011050073.1	SDR family NAD(P)-dependent oxidoreductase	-
HZS92_RS00445 (HZS92_00093)	101097..101834	-	738	WP_003487890.1	SDR family oxidoreductase	-
HZS92_RS00450 (HZS92_00094)	101960..102871	+	912	WP_011050074.1	LysR family transcriptional regulator	-
HZS92_RS00455 (HZS92_00095)	103037..104110	-	1074	WP_040107715.1	ATP-grasp fold amidoligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11231.97 Da
• Isoelectric Point: 9.7235

>T169663 WP_003487886.1 NZ_CP059999:99659-99958 [Xanthomonas citri pv. citri]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VVVHVMRSERALRGNRLSR

Nucleotide

• Length: 300 bp

>T169663 NZ_CP076653:2920262-2920612 [Bacillus sp. NP247]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGGAATCGTTTTAGTCCGACTGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGGGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT169663 WP_003487884.1 NZ_CP059999:99414-99671 [Xanthomonas citri pv. citri]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT169663 NZ_CP076653:2919970-2920257 [Bacillus sp. NP247]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Structures

Toxin

• AlphaFold DB: H8FI26

Antitoxin

• AlphaFold DB: H8FI25