Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 31550..32141 Replicon plasmid pSDCE1
Accession NZ_CP059996
Organism Sulfurospirillum sp. ACSDCE

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FA584_RS14255 Protein ID WP_191342113.1
Coordinates 31550..31804 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FA584_RS14260 Protein ID WP_191342114.1
Coordinates 31797..32141 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA584_RS14230 27254..27559 + 306 WP_167751067.1 hypothetical protein -
FA584_RS14235 27564..28466 + 903 WP_191342111.1 metallophosphoesterase -
FA584_RS14240 28471..28770 + 300 WP_167751063.1 hypothetical protein -
FA584_RS14245 30160..30768 - 609 WP_191342112.1 transposase -
FA584_RS14250 30946..31254 + 309 WP_167751061.1 hypothetical protein -
FA584_RS14255 31550..31804 + 255 WP_191342113.1 type II toxin-antitoxin system HicA family toxin Toxin
FA584_RS14260 31797..32141 + 345 WP_191342114.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FA584_RS14265 32293..32493 + 201 WP_191342115.1 hypothetical protein -
FA584_RS14270 32809..33654 + 846 WP_191342116.1 ParA family protein -
FA584_RS14275 33694..34683 + 990 WP_191342117.1 ParB N-terminal domain-containing protein -
FA584_RS14280 34808..35836 + 1029 WP_191342118.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39868 39868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(22-80)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9846.58 Da        Isoelectric Point: 10.0999

>T169660 WP_191342113.1 NZ_CP059996:31550-31804 [Sulfurospirillum sp. ACSDCE]
MSKRDKLWIKFMEVPPKKNLTWSDLLALMSALDFVQLEGDGSRVKFYHHAKDIVLNLHKPHPDNLLKTYLVKQIQEKLKE
AFNG

Download         Length: 255 bp

>T169660 NZ_CP076651:3772185-3772281 [Serratia ureilytica]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12912.68 Da        Isoelectric Point: 6.0785

>AT169660 WP_191342114.1 NZ_CP059996:31797-32141 [Sulfurospirillum sp. ACSDCE]
MANVLTYENYTGSVEYSHEDRCFFGKIEFINDLITFEATTVDELEANFKEAVESYILTCKALNRKPQKQFNGVFNVRPGV
ELHMAAARKAMEIGVSLNAYIKSLIAKDTHFSAH

Download         Length: 345 bp

>AT169660 NZ_CP076651:c3772281-3772141 [Serratia ureilytica]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References