Detailed information of TA system TA169659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 8554..9107
• Replicon: plasmid pSDCE1
• Accession: NZ_CP059996
• Organism: Sulfurospirillum sp. ACSDCE

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FA584_RS14125
• Protein ID: WP_167751037.1
• Coordinates: 8811..9107 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: FA584_RS14120
• Protein ID: WP_191342128.1
• Coordinates: 8554..8811 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FA584_RS14085	3819..4637	+	819	WP_025344704.1	IS21-like element helper ATPase IstB	-
FA584_RS14090	4800..5504	-	705	WP_191342125.1	hypothetical protein	-
FA584_RS14095	5593..5808	-	216	WP_191342126.1	hypothetical protein	-
FA584_RS14100	5983..7341	+	1359	WP_167750935.1	IS5 family transposase	-
FA584_RS14105	7418..7717	-	300	WP_191342127.1	hypothetical protein	-
FA584_RS14110	7915..8130	-	216	WP_167751038.1	hypothetical protein	-
FA584_RS14115	8284..8472	+	189	Protein_9	peptidase M28	-
FA584_RS14120	8554..8811	+	258	WP_191342128.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FA584_RS14125	8811..9107	+	297	WP_167751037.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FA584_RS14130	9229..9519	-	291	WP_167751036.1	HigA family addiction module antidote protein	-
FA584_RS14135	9555..9806	+	252	WP_191342129.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
FA584_RS14140	9803..10075	+	273	Protein_14	type II toxin-antitoxin system YafQ family toxin	-
FA584_RS14145	10134..10301	-	168	WP_191342130.1	hypothetical protein	-
FA584_RS14150	10434..11033	-	600	WP_191342131.1	hypothetical protein	-
FA584_RS14155	11036..11932	-	897	WP_191342132.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
FA584_RS14160	11925..12569	-	645	WP_191342133.1	hypothetical protein	-
FA584_RS14165	12722..13435	-	714	WP_191342134.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39868	39868
	-	flank	IS/Tn	-	-	7915..8130	215

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11923.65 Da
• Isoelectric Point: 6.9780

>T169659 WP_167751037.1 NZ_CP059996:8811-9107 [Sulfurospirillum sp. ACSDCE]
MYTPEYHRFFKKDIERDKKSGQFSAEDFTLLKEVMSAMLNDEILHEKYKNHPLKGEWEGTYECHIKNDWLLIYQIDNNTN
EMIFMRLGAHAQIFKKYK

Nucleotide

• Length: 297 bp

>T169659 NZ_CP076651:c3504248-3503964 [Serratia ureilytica]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9521.12 Da
• Isoelectric Point: 9.6916

>AT169659 WP_191342128.1 NZ_CP059996:8554-8811 [Sulfurospirillum sp. ACSDCE]
MTGTAMTVRIDPDIKNKAAEYLKQMGLTTSEATRLFLHSVVLHKGLPFELRIPNEKTVTAIKETKEGKNIIKHTSPKELF
DDLGL

Nucleotide

• Length: 258 bp

>AT169659 NZ_CP076651:c3504489-3504238 [Serratia ureilytica]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCTGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAATACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA