Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5622071..5622685 Replicon chromosome
Accession NZ_CP059995
Organism Pseudomonas aeruginosa strain 401853

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag H5J27_RS26695 Protein ID WP_071534354.1
Coordinates 5622503..5622685 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag H5J27_RS26690 Protein ID WP_012077229.1
Coordinates 5622071..5622475 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5J27_RS26665 5618211..5618921 + 711 WP_012074129.1 hypothetical protein -
H5J27_RS26670 5618918..5619838 + 921 WP_012074128.1 hypothetical protein -
H5J27_RS26675 5619835..5620374 + 540 WP_012074127.1 hypothetical protein -
H5J27_RS26680 5620374..5621072 + 699 WP_033896049.1 hypothetical protein -
H5J27_RS26685 5621057..5622028 + 972 WP_012077228.1 hypothetical protein -
H5J27_RS26690 5622071..5622475 - 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H5J27_RS26695 5622503..5622685 - 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
H5J27_RS26700 5623228..5624160 - 933 WP_079387315.1 ZIP family metal transporter -
H5J27_RS26705 5624179..5624790 - 612 WP_003098862.1 superoxide dismutase -
H5J27_RS26710 5624803..5625252 - 450 WP_003094369.1 hypothetical protein -
H5J27_RS26715 5625280..5626656 - 1377 WP_033970524.1 class II fumarate hydratase -
H5J27_RS26720 5626649..5627044 - 396 WP_003094374.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5584493..5622685 38192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T169657 WP_071534354.1 NZ_CP059995:c5622685-5622503 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T169657 NZ_CP076651:1964670-1964894 [Serratia ureilytica]
GTGGGATTCATCGCCAACGATAACCCTCTGGCGGCCAGAAAAATGAAGGTTCTCATCATGGAGGCCGTCACTCCCGCCGC
CAGGCATCCTCGAATTTTCCGGCGTGGCAGAGTGGACGGCACGCATGAAATCCCCTTGCATCCCCATTATCTCCTGATTT
ACCAGGTGCTGGAAACTCACATCCGGGTGTTGCGGGTATTACATACGCGCCGACAATATCCTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT169657 WP_012077229.1 NZ_CP059995:c5622475-5622071 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT169657 NZ_CP076651:1964424-1964624 [Serratia ureilytica]
ATGATGAGTATTTTACTACTGCCTACGGTTGCCAAGATGGAAAATGAGGAACACAAACAGGGCTATGAGCGCTGGTTTCT
TGAAAGAGTTCAGGAAGCCATGGATGAGCCGTGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTA
TCGCTGCTGCAGAAGCCAGGATCAACGCGAAGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References