Detailed information of TA system TA169655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4700899..4702156
• Replicon: chromosome
• Accession: NZ_CP059995
• Organism: Pseudomonas aeruginosa strain 401853

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A6A9JV85
• Locus tag: H5J27_RS21925
• Protein ID: WP_033969419.1
• Coordinates: 4700899..4701654 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H5J27_RS21930
• Protein ID: WP_042167402.1
• Coordinates: 4701788..4702156 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5J27_RS21915	4696068..4698611	+	2544	WP_079387358.1	acyl-homoserine-lactone acylase QuiP	-
H5J27_RS21920	4698766..4700127	-	1362	WP_003134034.1	DNA recombination protein RmuC	-
H5J27_RS21925	4700899..4701654	-	756	WP_033969419.1	RES family NAD+ phosphorylase	Toxin
H5J27_RS21930	4701788..4702156	-	369	WP_042167402.1	DUF2384 domain-containing protein	Antitoxin
H5J27_RS21935	4702229..4703515	-	1287	WP_042167399.1	FAD-binding oxidoreductase	-
H5J27_RS21940	4703569..4705158	-	1590	WP_079387357.1	aldehyde dehydrogenase family protein	-
H5J27_RS21945	4705236..4705712	+	477	WP_033976822.1	hypothetical protein	-
H5J27_RS21950	4705715..4705990	-	276	WP_177344468.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28253.37 Da
• Isoelectric Point: 8.0554

>T169655 WP_033969419.1 NZ_CP059995:c4701654-4700899 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQATPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVNGKLPHPA

Nucleotide

• Length: 756 bp

>T169655 NZ_CP076651:1191545-1191856 [Serratia ureilytica]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAGTACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCGTCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13366.64 Da
• Isoelectric Point: 10.2737

>AT169655 WP_042167402.1 NZ_CP059995:c4702156-4701788 [Pseudomonas aeruginosa]
MSALIKQRPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT169655 NZ_CP076651:1191853-1192275 [Serratia ureilytica]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTACCCTTATTGCAGGGCAGCCACGCTCAGCAAGA
CTACCGAGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACGCCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGCAAAAAGTCGTTGGTCAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCAGCCC
TGTTCCTGCCGGAAGCGGATTAA

Structures

Toxin

• AlphaFold DB: A0A6A9JV85