Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3771449..3772669 Replicon chromosome
Accession NZ_CP059995
Organism Pseudomonas aeruginosa strain 401853

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5J27_RS17530 Protein ID WP_042170883.1
Coordinates 3772091..3772669 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5J27_RS17525 Protein ID WP_042170884.1
Coordinates 3771449..3772003 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5J27_RS17500 3767020..3767571 + 552 WP_033978785.1 XRE family transcriptional regulator -
H5J27_RS17505 3767568..3767966 - 399 WP_023436383.1 NADH-quinone oxidoreductase subunit A -
H5J27_RS17510 3767979..3768302 - 324 WP_003102734.1 multidrug efflux SMR transporter -
H5J27_RS17515 3768633..3769094 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
H5J27_RS17520 3769099..3771294 + 2196 WP_083556322.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
H5J27_RS17525 3771449..3772003 + 555 WP_042170884.1 helix-turn-helix domain-containing protein Antitoxin
H5J27_RS17530 3772091..3772669 + 579 WP_042170883.1 HD domain-containing protein Toxin
H5J27_RS17535 3772778..3773965 - 1188 WP_042170881.1 HlyD family efflux transporter periplasmic adaptor subunit -
H5J27_RS17540 3773955..3776124 - 2170 Protein_3473 type I secretion system permease/ATPase -
H5J27_RS17545 3776114..3777391 - 1278 WP_003160086.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21825.64 Da        Isoelectric Point: 5.3655

>T169654 WP_042170883.1 NZ_CP059995:3772091-3772669 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLGGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T169654 NZ_CP076651:1133793-1134083 [Serratia ureilytica]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAGGCGCAGCCGTCTTATCCCCGGCGCGCT
CGAGCGGCAGTTGGCCAGAAAGCTCGATATGTTAGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCAAGGGTAACT
ATTACAAGCGGCTATCCGGGCCATTTCAGGGATGGTCGAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCCGAAAAAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20472.60 Da        Isoelectric Point: 8.1590

>AT169654 WP_042170884.1 NZ_CP059995:3771449-3772003 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLGEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPTRAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANTSAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT169654 NZ_CP076651:1134098-1134421 [Serratia ureilytica]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGAGAAGTGCTGCAGGAAGAATATTTAACGCCGTTAGGCATCGG
CCAAGAAGAACTGGCAAAGGTATTGGGCGTCACCCGCGCCACCGTCAATCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAATCTGTTTGCCGATCTGTTCGAAACGACCGCCGACTTTTGGCTAAACCTGCAGGCGGCACACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAGCGTGTGCGGCTGCGGCCAATCAAAGAAATACTGGGACGCAATATCACTCATGC
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References