Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1993717..1995225 Replicon chromosome
Accession NZ_CP059995
Organism Pseudomonas aeruginosa strain 401853

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag H5J27_RS09235 Protein ID WP_003119682.1
Coordinates 1993717..1994304 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag H5J27_RS09240 Protein ID WP_042168022.1
Coordinates 1994371..1995225 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5J27_RS09230 1989971..1993450 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
H5J27_RS09235 1993717..1994304 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
H5J27_RS09240 1994371..1995225 + 855 WP_042168022.1 AraC family transcriptional regulator Antitoxin
H5J27_RS09245 1995322..1997487 + 2166 WP_033968654.1 TonB-dependent receptor family protein -
H5J27_RS09250 1997662..1999536 + 1875 WP_033968656.1 MFS transporter -
H5J27_RS09255 1999598..1999807 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T169653 WP_003119682.1 NZ_CP059995:1993717-1994304 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T169653 NZ_CP076651:c867665-867243 [Serratia ureilytica]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTCTCTCTGTTGACCCACGGCGTCCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCTGCGGTGCAGGGTGAACTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGA
GAATGGCAGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTACAGCCTATGGAGGGCAAAAAGCG
CCGTCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGAGGCCTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT169653 WP_042168022.1 NZ_CP059995:1994371-1995225 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQARWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQTYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT169653 NZ_CP076651:c867912-867646 [Serratia ureilytica]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTCATCCGTCTGCTCGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAAAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References