Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 76248..76741 Replicon plasmid pT4p1
Accession NZ_CP059993
Organism Xanthomonas citri strain T4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HZS93_RS22645 Protein ID WP_015462614.1
Coordinates 76415..76741 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HZS93_RS22640 Protein ID WP_017157755.1
Coordinates 76248..76418 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS93_RS22615 (HZS93_06096) 71913..73133 + 1221 WP_011052984.1 TrbI/VirB10 family protein -
HZS93_RS22620 (HZS93_06097) 73144..74166 + 1023 WP_011052983.1 P-type DNA transfer ATPase VirB11 -
HZS93_RS22625 (HZS93_06098) 74177..75055 + 879 WP_011052982.1 lytic transglycosylase domain-containing protein -
HZS93_RS22630 (HZS93_06099) 75181..75600 + 420 WP_011052981.1 hypothetical protein -
HZS93_RS22635 (HZS93_06100) 75677..76063 + 387 WP_003491149.1 hypothetical protein -
HZS93_RS22640 (HZS93_06101) 76248..76418 + 171 WP_017157755.1 antitoxin MazE family protein Antitoxin
HZS93_RS22645 (HZS93_06102) 76415..76741 + 327 WP_015462614.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HZS93_RS22650 (HZS93_06103) 76795..79770 - 2976 WP_011052978.1 MobF family relaxase -
HZS93_RS22655 (HZS93_06104) 79784..81358 - 1575 WP_011052977.1 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99130 99130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11676.70 Da        Isoelectric Point: 9.2550

>T169651 WP_015462614.1 NZ_CP059993:76415-76741 [Xanthomonas citri]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T169651 NZ_CP076651:c65552-65199 [Serratia ureilytica]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCGCTTAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6518.34 Da        Isoelectric Point: 4.1476

>AT169651 WP_017157755.1 NZ_CP059993:76248-76418 [Xanthomonas citri]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT169651 NZ_CP076651:c65194-64892 [Serratia ureilytica]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References