Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5120128..5120795 Replicon chromosome
Accession NZ_CP059992
Organism Xanthomonas citri strain T4

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag HZS93_RS21915 Protein ID WP_005916679.1
Coordinates 5120379..5120795 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag HZS93_RS21910 Protein ID WP_005916676.1
Coordinates 5120128..5120382 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS93_RS21885 5116290..5116469 + 180 WP_011052886.1 RNA 2'-phosphotransferase -
HZS93_RS21890 (HZS93_04634) 5116626..5117891 + 1266 WP_015463799.1 phospholipase D-like domain-containing protein -
HZS93_RS21895 (HZS93_04635) 5117917..5118444 - 528 WP_005916668.1 hypothetical protein -
HZS93_RS21900 (HZS93_04636) 5118683..5118889 + 207 WP_003489327.1 hypothetical protein -
HZS93_RS21905 (HZS93_04637) 5118876..5119982 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZS93_RS21910 (HZS93_04638) 5120128..5120382 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
HZS93_RS21915 (HZS93_04639) 5120379..5120795 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
HZS93_RS21920 (HZS93_04640) 5120917..5121120 - 204 WP_125460668.1 hypothetical protein -
HZS93_RS21925 (HZS93_04641) 5121248..5121460 - 213 WP_015472901.1 hypothetical protein -
HZS93_RS21930 (HZS93_04642) 5121717..5123336 + 1620 WP_015463800.1 alpha/beta hydrolase-fold protein -
HZS93_RS21935 (HZS93_04643) 5123440..5123838 - 399 WP_004429277.1 DUF2384 domain-containing protein -
HZS93_RS21940 (HZS93_04644) 5124154..5124585 + 432 WP_005922907.1 hypothetical protein -
HZS93_RS21945 5124614..5124844 - 231 WP_223293191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T169648 WP_005916679.1 NZ_CP059992:5120379-5120795 [Xanthomonas citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T169648 NZ_CP076649:c8224-7943 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT169648 WP_005916676.1 NZ_CP059992:5120128-5120382 [Xanthomonas citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT169648 NZ_CP076649:c8465-8214 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References