Detailed information of TA system TA169644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 99414..99958
• Replicon: chromosome
• Accession: NZ_CP059992
• Organism: Xanthomonas citri strain T4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HZS93_RS00430
• Protein ID: WP_015462700.1
• Coordinates: 99680..99958 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: HZS93_RS00425
• Protein ID: WP_003487884.1
• Coordinates: 99414..99671 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS93_RS00410 (HZS93_00086)	94533..96014	-	1482	WP_015462698.1	ribonuclease H-like domain-containing protein	-
HZS93_RS00415 (HZS93_00087)	96011..98506	-	2496	WP_015462699.1	DEAD/DEAH box helicase	-
HZS93_RS00420 (HZS93_00088)	98684..99346	+	663	WP_005912558.1	hemolysin III family protein	-
HZS93_RS00425 (HZS93_00089)	99414..99671	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HZS93_RS00430 (HZS93_00090)	99680..99958	+	279	WP_015462700.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZS93_RS00440 (HZS93_00092)	100138..101037	-	900	WP_011050073.1	SDR family NAD(P)-dependent oxidoreductase	-
HZS93_RS00445 (HZS93_00093)	101097..101834	-	738	WP_003487890.1	SDR family oxidoreductase	-
HZS93_RS00450 (HZS93_00094)	101960..102871	+	912	WP_011050074.1	LysR family transcriptional regulator	-
HZS93_RS00455 (HZS93_00095)	103037..104110	-	1074	WP_040107715.1	ATP-grasp fold amidoligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10400.97 Da
• Isoelectric Point: 10.1557

>T169644 WP_015462700.1 NZ_CP059992:99680-99958 [Xanthomonas citri]
VPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRIVVVHVMR
SERALRGNRLSR

Nucleotide

• Length: 279 bp

>T169644 NZ_CP076646:c4042869-4042582 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAATACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT169644 WP_003487884.1 NZ_CP059992:99414-99671 [Xanthomonas citri]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT169644 NZ_CP076646:c4042595-4042293 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: H8FI25