Detailed information of TA system TA169641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 966074..966557
• Replicon: chromosome
• Accession: NZ_CP059986
• Organism: Morganella morganii strain 11759

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J7TMG3
• Locus tag: H4431_RS04455
• Protein ID: WP_004237651.1
• Coordinates: 966330..966557 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H4431_RS04450
• Protein ID: WP_015422945.1
• Coordinates: 966074..966346 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4431_RS04445 (H4431_04445)	961231..965865	+	4635	WP_182095785.1	hemagglutinin repeat-containing protein	-
H4431_RS04450 (H4431_04450)	966074..966346	+	273	WP_015422945.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H4431_RS04455 (H4431_04455)	966330..966557	+	228	WP_004237651.1	type II toxin-antitoxin system YafQ family toxin	Toxin
H4431_RS04460 (H4431_04460)	966860..968344	+	1485	WP_004237652.1	C69 family dipeptidase	-
H4431_RS04465 (H4431_04465)	968410..968862	-	453	WP_004237653.1	NfeD family protein	-
H4431_RS04470 (H4431_04470)	968859..969797	-	939	WP_032099238.1	SPFH domain-containing protein	-
H4431_RS04475 (H4431_04475)	969853..970710	-	858	WP_015422944.1	co-chaperone YbbN	-
H4431_RS04480 (H4431_04480)	970770..971555	-	786	WP_062771820.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-74)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-78)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9069.63 Da
• Isoelectric Point: 9.9416

>T169641 WP_004237651.1 NZ_CP059986:966330-966557 [Morganella morganii]
MARTIERSSQFKKDYKREVKGIYRMMLNDSLQNILNILVNDLPIPEKYADHPLKGNWRTFRDCHLYPDLILIYKK

Nucleotide

• Length: 228 bp

>T169641 NZ_CP076646:c3046165-3045782 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10091.70 Da
• Isoelectric Point: 5.1746

>AT169641 WP_015422945.1 NZ_CP059986:966074-966346 [Morganella morganii]
VEYVRAKIDPKLKAEAIETLESMGLTVSDAIRMLMIQIVEQKAMPFCVKSTQYRHAARTRAAIEELECGKGKKFDSISDL
MADLQDGKDD

Nucleotide

• Length: 273 bp

>AT169641 NZ_CP076646:c3046622-3046242 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCATCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Structures

Toxin

• AlphaFold DB: J7TMG3