Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4876497..4877032 Replicon chromosome
Accession NZ_CP059963
Organism Pectobacterium brasiliense strain IPO:3649 NAK:375

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag H5A23_RS21490 Protein ID WP_015842269.1
Coordinates 4876497..4876784 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag H5A23_RS21495 Protein ID WP_010281712.1
Coordinates 4876781..4877032 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A23_RS21465 4871809..4872537 - 729 WP_039498362.1 DUF1266 domain-containing protein -
H5A23_RS21470 4872710..4873270 + 561 Protein_4191 alkyl/aryl-sulfatase -
H5A23_RS21475 4873392..4873775 + 384 WP_014913665.1 TfoX/Sxy family protein -
H5A23_RS21480 4874056..4874898 + 843 WP_010281707.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
H5A23_RS21485 4875027..4876379 + 1353 WP_119871553.1 glutathione-disulfide reductase -
H5A23_RS21490 4876497..4876784 - 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A23_RS21495 4876781..4877032 - 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5A23_RS21500 4877287..4878192 + 906 WP_119871554.1 siderophore-interacting protein -
H5A23_RS21505 4878226..4878981 - 756 WP_119871555.1 thiol:disulfide interchange protein DsbG -
H5A23_RS21510 4879249..4879872 + 624 WP_119871556.1 LysE family translocator -
H5A23_RS21515 4879932..4880972 - 1041 WP_119871557.1 HipA domain-containing protein -
H5A23_RS21520 4880969..4881283 - 315 WP_039279922.1 HipA N-terminal domain-containing protein -
H5A23_RS21525 4881268..4881594 - 327 WP_039510297.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T169637 WP_015842269.1 NZ_CP059963:c4876784-4876497 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T169637 NZ_CP076646:2094586-2094689 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT169637 WP_010281712.1 NZ_CP059963:c4877032-4876781 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT169637 NZ_CP076646:c2094727-2094456 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References