Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4730881..4732469 Replicon chromosome
Accession NZ_CP059963
Organism Pectobacterium brasiliense strain IPO:3649 NAK:375

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H5A23_RS20835 Protein ID WP_119870763.1
Coordinates 4730881..4732200 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H5A23_RS20840 Protein ID WP_103943261.1
Coordinates 4732200..4732469 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A23_RS20810 4726978..4727118 + 141 WP_005976668.1 50S ribosomal protein L34 -
H5A23_RS20815 4727137..4727496 + 360 WP_010281235.1 ribonuclease P protein component -
H5A23_RS20820 4727460..4727717 + 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
H5A23_RS20825 4727720..4729354 + 1635 WP_010281240.1 membrane protein insertase YidC -
H5A23_RS20830 4729484..4730848 + 1365 WP_119870764.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
H5A23_RS20835 4730881..4732200 - 1320 WP_119870763.1 type II toxin-antitoxin system HipA family toxin Toxin
H5A23_RS20840 4732200..4732469 - 270 WP_103943261.1 helix-turn-helix domain-containing protein Antitoxin
H5A23_RS20845 4732662..4732928 - 267 Protein_4071 alpha/beta hydrolase -
H5A23_RS20850 4733057..4733908 - 852 WP_119870762.1 SDR family oxidoreductase -
H5A23_RS20855 4734051..4734461 + 411 WP_094431545.1 helix-turn-helix transcriptional regulator -
H5A23_RS20860 4734492..4735043 - 552 WP_119870761.1 TetR/AcrR family transcriptional regulator -
H5A23_RS20865 4735147..4736649 + 1503 WP_119870760.1 MFS transporter -
H5A23_RS20870 4736772..4737431 - 660 WP_014917137.1 DUF799 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-103)

Antitoxin

(14-66)


Sequences


Toxin        


Download         Length: 440 a.a.        Molecular weight: 49397.67 Da        Isoelectric Point: 6.6897

>T169636 WP_119870763.1 NZ_CP059963:c4732200-4730881 [Pectobacterium brasiliense]
MAALDVYMNGYRVGILTKTGSGAHHFSYDTNWLGLLGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
TDSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDRWCLPLNVTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVYPERDRYRFMQTQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKVVGFARESMENILAEFAQTV
DTVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T169636 NZ_CP076646:c1837684-1837310 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.40 Da        Isoelectric Point: 9.7281

>AT169636 WP_103943261.1 NZ_CP059963:c4732469-4732200 [Pectobacterium brasiliense]
MMKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEAS
VASSWKEEW

Download         Length: 270 bp

>AT169636 NZ_CP076646:c1838141-1837773 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References