Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 4565851..4566485 Replicon chromosome
Accession NZ_CP059963
Organism Pectobacterium brasiliense strain IPO:3649 NAK:375

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H5A23_RS20130 Protein ID WP_014917023.1
Coordinates 4566210..4566485 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A433N1R7
Locus tag H5A23_RS20125 Protein ID WP_014917022.1
Coordinates 4565851..4566213 (-) Length 121 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A23_RS20105 4560980..4561864 - 885 WP_014917008.1 N-carbamoylputrescine amidase -
H5A23_RS20110 4562145..4563107 - 963 WP_010281567.1 6-phosphofructokinase -
H5A23_RS20115 4563315..4564217 - 903 WP_119870811.1 CDF family cation-efflux transporter FieF -
H5A23_RS20120 4564290..4565477 - 1188 WP_080162913.1 sugar transporter -
H5A23_RS20125 4565851..4566213 - 363 WP_014917022.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H5A23_RS20130 4566210..4566485 - 276 WP_014917023.1 type II toxin-antitoxin system HicA family toxin Toxin
H5A23_RS20135 4566722..4567246 - 525 WP_014917024.1 cell-envelope stress modulator CpxP -
H5A23_RS20140 4567400..4568098 + 699 WP_010281574.1 envelope stress response regulator transcription factor CpxR -
H5A23_RS20145 4568095..4569465 + 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-85)

Antitoxin

(61-113)


Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10050.70 Da        Isoelectric Point: 11.1875

>T169633 WP_014917023.1 NZ_CP059963:c4566485-4566210 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLIQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Download         Length: 276 bp

>T169633 NZ_CP076646:1005238-1005573 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13504.31 Da        Isoelectric Point: 4.4969

>AT169633 WP_014917022.1 NZ_CP059963:c4566213-4565851 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA

Download         Length: 363 bp

>AT169633 NZ_CP076646:1004990-1005238 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A433N1R7

References