Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 4565851..4566485 | Replicon | chromosome |
Accession | NZ_CP059963 | ||
Organism | Pectobacterium brasiliense strain IPO:3649 NAK:375 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | H5A23_RS20130 | Protein ID | WP_014917023.1 |
Coordinates | 4566210..4566485 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A433N1R7 |
Locus tag | H5A23_RS20125 | Protein ID | WP_014917022.1 |
Coordinates | 4565851..4566213 (-) | Length | 121 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5A23_RS20105 | 4560980..4561864 | - | 885 | WP_014917008.1 | N-carbamoylputrescine amidase | - |
H5A23_RS20110 | 4562145..4563107 | - | 963 | WP_010281567.1 | 6-phosphofructokinase | - |
H5A23_RS20115 | 4563315..4564217 | - | 903 | WP_119870811.1 | CDF family cation-efflux transporter FieF | - |
H5A23_RS20120 | 4564290..4565477 | - | 1188 | WP_080162913.1 | sugar transporter | - |
H5A23_RS20125 | 4565851..4566213 | - | 363 | WP_014917022.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
H5A23_RS20130 | 4566210..4566485 | - | 276 | WP_014917023.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
H5A23_RS20135 | 4566722..4567246 | - | 525 | WP_014917024.1 | cell-envelope stress modulator CpxP | - |
H5A23_RS20140 | 4567400..4568098 | + | 699 | WP_010281574.1 | envelope stress response regulator transcription factor CpxR | - |
H5A23_RS20145 | 4568095..4569465 | + | 1371 | WP_010281575.1 | envelope stress sensor histidine kinase CpxA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10050.70 Da Isoelectric Point: 11.1875
>T169633 WP_014917023.1 NZ_CP059963:c4566485-4566210 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLIQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP
MQGKIASLRKKQRETLIQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP
Download Length: 276 bp
>T169633 NZ_CP076646:1005238-1005573 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 121 a.a. Molecular weight: 13504.31 Da Isoelectric Point: 4.4969
>AT169633 WP_014917022.1 NZ_CP059963:c4566213-4565851 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA
Download Length: 363 bp
>AT169633 NZ_CP076646:1004990-1005238 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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