169627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1006880..1007916 Replicon chromosome
Accession NZ_CP059963
Organism Pectobacterium brasiliense strain IPO:3649 NAK:375

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag H5A23_RS04685 Protein ID WP_119871526.1
Coordinates 1007341..1007916 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag H5A23_RS04680 Protein ID WP_119871525.1
Coordinates 1006880..1007341 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A23_RS04660 1001941..1002474 + 534 WP_010282870.1 RNA pyrophosphohydrolase -
H5A23_RS04665 1002487..1004733 + 2247 WP_039283946.1 phosphoenolpyruvate--protein phosphotransferase -
H5A23_RS04670 1004960..1005826 + 867 WP_010286783.1 prolipoprotein diacylglyceryl transferase -
H5A23_RS04675 1005863..1006657 + 795 WP_039312476.1 thymidylate synthase -
H5A23_RS04680 1006880..1007341 + 462 WP_119871525.1 helix-turn-helix domain-containing protein Antitoxin
H5A23_RS04685 1007341..1007916 + 576 WP_119871526.1 PIN domain-containing protein Toxin
H5A23_RS04690 1008096..1008599 + 504 WP_119871527.1 prepilin peptidase-dependent protein -
H5A23_RS04695 1008593..1009219 + 627 WP_119871528.1 prepilin peptidase-dependent protein -
H5A23_RS04700 1009255..1009671 + 417 WP_119871529.1 YgdB family protein -
H5A23_RS04705 1009658..1010053 + 396 WP_014914413.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21493.91 Da        Isoelectric Point: 4.7230

>T169627 WP_119871526.1 NZ_CP059963:1007341-1007916 [Pectobacterium brasiliense]
MNHSPYPVVLDACVIYPSLLRDLLMHLGLTGLYQPKWTVLIQEEWQRNLLLNNADVTMDKLRNIEHLMNKALPDANVTGF
EQLIPALVLPDADDRHVLAAAIRANAEVIVTANLKDFPATSLSEFGVEAMHPDEFIADLFDLNSALVLKAVRTSRTAFRK
PPFDVDEYLDCLLRQGLPMTVKELDAYRALI

Download         Length: 576 bp

>T169627 NZ_CP076645:c4554774-4554601 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17277.78 Da        Isoelectric Point: 6.2253

>AT169627 WP_119871525.1 NZ_CP059963:1006880-1007341 [Pectobacterium brasiliense]
MKNTPLNSLSLPAPKEMEAAIRGQRQLATYLSTKLETQEISIQDAHDIAHRIELPTSALTLLMSILGELAAGNAVQIVPV
QAELTTQEAANILNVSRPHMVKLLEEGHLPFHKTGRHRRVLFADLMQYKEQRENESMQAMQELTDRSQEFGFY

Download         Length: 462 bp

>AT169627 NZ_CP076645:c4555098-4554802 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References