169621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 134984..135515 Replicon chromosome
Accession NZ_CP059963
Organism Pectobacterium brasiliense strain IPO:3649 NAK:375

Toxin (Protein)


Gene name stbE Uniprot ID A0A086EVU3
Locus tag H5A23_RS00660 Protein ID WP_039282785.1
Coordinates 135228..135515 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A1V2R9J2
Locus tag H5A23_RS00655 Protein ID WP_039282788.1
Coordinates 134984..135238 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A23_RS00630 130185..130775 - 591 WP_005975525.1 DnaA initiator-associating protein DiaA -
H5A23_RS00635 130839..131234 - 396 WP_072036118.1 YraN family protein -
H5A23_RS00640 131192..133210 - 2019 WP_039282794.1 penicillin-binding protein activator -
H5A23_RS00645 133272..134159 + 888 WP_039556326.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
H5A23_RS00655 134984..135238 + 255 WP_039282788.1 plasmid stabilization protein Antitoxin
H5A23_RS00660 135228..135515 + 288 WP_039282785.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A23_RS00665 135713..136498 + 786 WP_119871053.1 4,5-DOPA dioxygenase extradiol -
H5A23_RS00670 136566..137726 - 1161 WP_039462681.1 glutathionylspermidine synthase family protein -
H5A23_RS00675 137738..138412 - 675 WP_010280216.1 DUF1190 family protein -
H5A23_RS00680 138683..140074 - 1392 WP_039282780.1 outer membrane channel protein TolC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11011.96 Da        Isoelectric Point: 10.7694

>T169621 WP_039282785.1 NZ_CP059963:135228-135515 [Pectobacterium brasiliense]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Download         Length: 288 bp

>T169621 NZ_CP076645:2828399-2828506 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9208.38 Da        Isoelectric Point: 3.7947

>AT169621 WP_039282788.1 NZ_CP059963:134984-135238 [Pectobacterium brasiliense]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Download         Length: 255 bp

>AT169621 NZ_CP076645:c2828349-2828286 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGGTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086EVU3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2R9J2

References