Detailed information of TA system TA169618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4959561..4960144
• Replicon: chromosome
• Accession: NZ_CP059962
• Organism: Pectobacterium brasiliense strain IPO:3710 NAK:380

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H5A25_RS21855
• Protein ID: WP_119871112.1
• Coordinates: 4959839..4960144 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H5A25_RS21850
• Protein ID: WP_119871111.1
• Coordinates: 4959561..4959851 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5A25_RS21830	4954696..4955958	-	1263	WP_039282588.1	L-rhamnose isomerase	-
H5A25_RS21835	4955942..4957444	-	1503	WP_205592508.1	rhamnulokinase	-
H5A25_RS21840	4957781..4958620	+	840	WP_014913998.1	HTH-type transcriptional activator RhaS	-
H5A25_RS21845	4958645..4959499	+	855	WP_119871110.1	helix-turn-helix domain-containing protein	-
H5A25_RS21850	4959561..4959851	+	291	WP_119871111.1	ribbon-helix-helix protein, CopG family	Antitoxin
H5A25_RS21855	4959839..4960144	+	306	WP_119871112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H5A25_RS21860	4960204..4961913	-	1710	WP_119871113.1	ABC transporter ATP-binding protein	-
H5A25_RS21865	4961910..4962776	-	867	WP_010285293.1	ABC transporter permease	-
H5A25_RS21870	4962769..4963728	-	960	WP_039279295.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11602.42 Da
• Isoelectric Point: 9.4590

>T169618 WP_119871112.1 NZ_CP059962:4959839-4960144 [Pectobacterium brasiliense]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVVLYRHDE
LTDRVVILTVKHQKEAGYQNP

Nucleotide

• Length: 306 bp

>T169618 NZ_CP076645:2154477-2154580 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11100.17 Da
• Isoelectric Point: 4.7845

>AT169618 WP_119871111.1 NZ_CP059962:4959561-4959851 [Pectobacterium brasiliense]
MADTPRQTTTLRIDQDIKERLKTLADDRHSSAHALMLEAITEYVEREEKRSQYRKEALAAWEEYQSTGEHITADETVTWL
ESWGSGHEQDAPACHK

Nucleotide

• Length: 291 bp

>AT169618 NZ_CP076645:c2154618-2154347 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT