Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4353918..4355506 Replicon chromosome
Accession NZ_CP059962
Organism Pectobacterium brasiliense strain IPO:3710 NAK:380

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H5A25_RS19080 Protein ID WP_119870763.1
Coordinates 4353918..4355237 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H5A25_RS19085 Protein ID WP_103943261.1
Coordinates 4355237..4355506 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A25_RS19055 4350015..4350155 + 141 WP_005976668.1 50S ribosomal protein L34 -
H5A25_RS19060 4350174..4350533 + 360 WP_010281235.1 ribonuclease P protein component -
H5A25_RS19065 4350497..4350754 + 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
H5A25_RS19070 4350757..4352391 + 1635 WP_010281240.1 membrane protein insertase YidC -
H5A25_RS19075 4352521..4353885 + 1365 WP_119870764.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
H5A25_RS19080 4353918..4355237 - 1320 WP_119870763.1 type II toxin-antitoxin system HipA family toxin Toxin
H5A25_RS19085 4355237..4355506 - 270 WP_103943261.1 helix-turn-helix domain-containing protein Antitoxin
H5A25_RS19090 4355699..4355965 - 267 Protein_3735 alpha/beta hydrolase -
H5A25_RS19095 4356094..4356945 - 852 WP_119870762.1 SDR family oxidoreductase -
H5A25_RS19100 4357088..4357498 + 411 WP_094431545.1 helix-turn-helix transcriptional regulator -
H5A25_RS19105 4357529..4358080 - 552 WP_119870761.1 TetR/AcrR family transcriptional regulator -
H5A25_RS19110 4358184..4359686 + 1503 WP_119870760.1 MFS transporter -
H5A25_RS19115 4359809..4360468 - 660 WP_014917137.1 DUF799 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49397.67 Da        Isoelectric Point: 6.6897

>T169613 WP_119870763.1 NZ_CP059962:c4355237-4353918 [Pectobacterium brasiliense]
MAALDVYMNGYRVGILTKTGSGAHHFSYDTNWLGLLGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
TDSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDRWCLPLNVTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVYPERDRYRFMQTQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKVVGFARESMENILAEFAQTV
DTVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T169613 NZ_CP076645:719201-719497 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.40 Da        Isoelectric Point: 9.7281

>AT169613 WP_103943261.1 NZ_CP059962:c4355506-4355237 [Pectobacterium brasiliense]
MMKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEAS
VASSWKEEW

Download         Length: 270 bp

>AT169613 NZ_CP076645:719499-719894 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References