Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4188889..4189523 Replicon chromosome
Accession NZ_CP059962
Organism Pectobacterium brasiliense strain IPO:3710 NAK:380

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H5A25_RS18375 Protein ID WP_014917023.1
Coordinates 4189248..4189523 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A433N1R7
Locus tag H5A25_RS18370 Protein ID WP_014917022.1
Coordinates 4188889..4189251 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A25_RS18350 4184018..4184902 - 885 WP_014917008.1 N-carbamoylputrescine amidase -
H5A25_RS18355 4185183..4186145 - 963 WP_010281567.1 6-phosphofructokinase -
H5A25_RS18360 4186353..4187255 - 903 WP_119870811.1 CDF family cation-efflux transporter FieF -
H5A25_RS18365 4187328..4188515 - 1188 WP_080162913.1 sugar transporter -
H5A25_RS18370 4188889..4189251 - 363 WP_014917022.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H5A25_RS18375 4189248..4189523 - 276 WP_014917023.1 type II toxin-antitoxin system HicA family toxin Toxin
H5A25_RS18380 4189760..4190284 - 525 WP_014917024.1 cell-envelope stress modulator CpxP -
H5A25_RS18385 4190438..4191136 + 699 WP_010281574.1 envelope stress response regulator transcription factor CpxR -
H5A25_RS18390 4191133..4192503 + 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10050.70 Da        Isoelectric Point: 11.1875

>T169610 WP_014917023.1 NZ_CP059962:c4189523-4189248 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLIQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Download         Length: 276 bp

>T169610 NZ_CP076645:184975-185082 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13504.31 Da        Isoelectric Point: 4.4969

>AT169610 WP_014917022.1 NZ_CP059962:c4189251-4188889 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA

Download         Length: 363 bp

>AT169610 NZ_CP076645:c184927-184861 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A433N1R7

References