Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 4188889..4189523 | Replicon | chromosome |
Accession | NZ_CP059962 | ||
Organism | Pectobacterium brasiliense strain IPO:3710 NAK:380 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | H5A25_RS18375 | Protein ID | WP_014917023.1 |
Coordinates | 4189248..4189523 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A433N1R7 |
Locus tag | H5A25_RS18370 | Protein ID | WP_014917022.1 |
Coordinates | 4188889..4189251 (-) | Length | 121 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5A25_RS18350 | 4184018..4184902 | - | 885 | WP_014917008.1 | N-carbamoylputrescine amidase | - |
H5A25_RS18355 | 4185183..4186145 | - | 963 | WP_010281567.1 | 6-phosphofructokinase | - |
H5A25_RS18360 | 4186353..4187255 | - | 903 | WP_119870811.1 | CDF family cation-efflux transporter FieF | - |
H5A25_RS18365 | 4187328..4188515 | - | 1188 | WP_080162913.1 | sugar transporter | - |
H5A25_RS18370 | 4188889..4189251 | - | 363 | WP_014917022.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
H5A25_RS18375 | 4189248..4189523 | - | 276 | WP_014917023.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
H5A25_RS18380 | 4189760..4190284 | - | 525 | WP_014917024.1 | cell-envelope stress modulator CpxP | - |
H5A25_RS18385 | 4190438..4191136 | + | 699 | WP_010281574.1 | envelope stress response regulator transcription factor CpxR | - |
H5A25_RS18390 | 4191133..4192503 | + | 1371 | WP_010281575.1 | envelope stress sensor histidine kinase CpxA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10050.70 Da Isoelectric Point: 11.1875
>T169610 WP_014917023.1 NZ_CP059962:c4189523-4189248 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLIQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP
MQGKIASLRKKQRETLIQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP
Download Length: 276 bp
>T169610 NZ_CP076645:184975-185082 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 121 a.a. Molecular weight: 13504.31 Da Isoelectric Point: 4.4969
>AT169610 WP_014917022.1 NZ_CP059962:c4189251-4188889 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA
Download Length: 363 bp
>AT169610 NZ_CP076645:c184927-184861 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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