Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4165092..4165709 Replicon chromosome
Accession NZ_CP059962
Organism Pectobacterium brasiliense strain IPO:3710 NAK:380

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag H5A25_RS18245 Protein ID WP_010281507.1
Coordinates 4165092..4165271 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A086ESS8
Locus tag H5A25_RS18250 Protein ID WP_014916995.1
Coordinates 4165299..4165709 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A25_RS18220 4160333..4161493 - 1161 WP_039465321.1 cystathionine gamma-synthase -
H5A25_RS18225 4161681..4161998 + 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
H5A25_RS18230 4162232..4163029 + 798 WP_119870818.1 ABC transporter ATP-binding protein -
H5A25_RS18235 4163039..4164001 + 963 WP_014916993.1 ABC transporter substrate-binding protein -
H5A25_RS18240 4163998..4165008 + 1011 WP_119870817.1 iron ABC transporter permease -
H5A25_RS18245 4165092..4165271 + 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
H5A25_RS18250 4165299..4165709 + 411 WP_014916995.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H5A25_RS18255 4165806..4166021 - 216 WP_010281510.1 50S ribosomal protein L31 -
H5A25_RS18260 4166295..4168493 + 2199 WP_104209601.1 primosomal protein N' -
H5A25_RS18265 4168802..4169845 + 1044 WP_010281514.1 DNA-binding transcriptional regulator CytR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T169609 WP_010281507.1 NZ_CP059962:4165092-4165271 [Pectobacterium brasiliense]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T169609 NZ_CP076643:c1583172-1581844 [Vibrio ostreae]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGATTGGGTTTCAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGGTATGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTGCTGCCAGATAATCAGCAGATACGAGATAGAATAGCTGCTCGCTAT
AAAGCAGATACTAAACAGCCATTCGACCTATTAGCTAAGGTTGGTCGAGATGCTGTTGGTGCTATCACGCTAGTTCCAGA
AGGCTTTGATGTAGATGATCATCGAGTTATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGACGCTCCTTTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTGTTTCACGATGGAAGATGGATGCTACCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCTAGTGTAGATAATGAGTTGATTTGTATGAGGCTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCTGTTGAGCGATTTGACCGA
AAATTATCTTCTGATAACAGCTATTACTTGCGCTTGCCCCATGAGGATTTTTGCCAGGCAAAAGGGATTCCCTCAGCTAG
AAAATATGAAATTGACGGTGGTATCGGCATAGAAGAATCTATTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATTTCGGCACATCCACTGGCAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGTACTAGTGGTCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTTGAAGATACCTTTCACACTATGAACGTCCCGAACATTAGGCGAGAAAAGGTTCGCTTATTGCTTGATGAGTTCGAA
TCGACGGCAAGGGCGGTGATTGATTCTGTCGGAAACTCGCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAGATTCAATTGACAAAAAAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14506.39 Da        Isoelectric Point: 4.3391

>AT169609 WP_014916995.1 NZ_CP059962:4165299-4165709 [Pectobacterium brasiliense]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKSAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT169609 NZ_CP076643:c1583405-1583166 [Vibrio ostreae]
ATGCTAGTTAACACACCGACAGCCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAACGGCCTAAAGCAAACAGATCT
TGGTCTGCGGCAAGCAACGGTATCAAATTTTGAAAGCAACCCTGAAAAATCCACGATAGAAACATTATTCAAGCTCCTGT
CTATCAATGGGCTAGAAATGCATATTGTGCCTAAAGGCAAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A086ESS8

References