Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2540720..2541345 Replicon chromosome
Accession NZ_CP059961
Organism Pectobacterium brasiliense strain IPO:4057 NAK:249

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag H5A39_RS11550 Protein ID WP_005976087.1
Coordinates 2540720..2540923 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag H5A39_RS11555 Protein ID WP_010282247.1
Coordinates 2540977..2541345 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A39_RS11520 2536053..2536391 + 339 WP_002208627.1 P-II family nitrogen regulator -
H5A39_RS11525 2536431..2537717 + 1287 WP_185893748.1 ammonium transporter AmtB -
H5A39_RS11530 2537857..2538720 - 864 WP_119872106.1 acyl-CoA thioesterase II -
H5A39_RS11535 2538933..2539514 + 582 WP_119872105.1 YbaY family lipoprotein -
H5A39_RS11540 2539516..2539854 - 339 WP_119872104.1 MGMT family protein -
H5A39_RS11550 2540720..2540923 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
H5A39_RS11555 2540977..2541345 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
H5A39_RS11560 2541944..2542087 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
H5A39_RS11565 2542105..2542353 - 249 WP_039274617.1 type B 50S ribosomal protein L31 -
H5A39_RS11570 2542584..2545712 - 3129 WP_039511040.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T169600 WP_005976087.1 NZ_CP059961:c2540923-2540720 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T169600 NZ_CP076623:c895631-895428 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT169600 WP_010282247.1 NZ_CP059961:c2541345-2540977 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT169600 NZ_CP076623:c896053-895694 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCTTCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAAAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTGGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References