Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1603544..1604070 Replicon chromosome
Accession NZ_CP059961
Organism Pectobacterium brasiliense strain IPO:4057 NAK:249

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag H5A39_RS07230 Protein ID WP_119871147.1
Coordinates 1603544..1603849 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID C6C380
Locus tag H5A39_RS07235 Protein ID WP_015855076.1
Coordinates 1603852..1604070 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A39_RS07200 1598545..1598799 - 255 WP_119871224.1 helix-turn-helix domain-containing protein -
H5A39_RS07205 1598903..1599145 + 243 WP_072010299.1 helix-turn-helix domain-containing protein -
H5A39_RS07210 1599485..1599778 + 294 WP_038921611.1 DUF1778 domain-containing protein -
H5A39_RS07215 1599775..1600269 + 495 WP_119871144.1 GNAT family N-acetyltransferase -
H5A39_RS07220 1600695..1602416 + 1722 WP_119871145.1 AAA family ATPase -
H5A39_RS07225 1602502..1603344 + 843 WP_119871146.1 DNA adenine methylase -
H5A39_RS07230 1603544..1603849 - 306 WP_119871147.1 type II toxin-antitoxin system toxin CcdB Toxin
H5A39_RS07235 1603852..1604070 - 219 WP_015855076.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
H5A39_RS07240 1604129..1604872 - 744 WP_119871148.1 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
H5A39_RS07245 1604965..1605315 + 351 WP_158586005.1 hypothetical protein -
H5A39_RS07250 1605769..1606110 - 342 WP_119871225.1 hypothetical protein -
H5A39_RS07255 1606296..1606490 + 195 WP_044209559.1 DUF3950 domain-containing protein -
H5A39_RS07260 1606606..1607868 - 1263 WP_119871150.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1599229..1608045 8816


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11759.63 Da        Isoelectric Point: 4.6533

>T169597 WP_119871147.1 NZ_CP059961:c1603849-1603544 [Pectobacterium brasiliense]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAYHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEVT
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T169597 NZ_CP076619:c4743539-4743387 [Xanthomonas arboricola pv. corylina]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8178.13 Da        Isoelectric Point: 7.0135

>AT169597 WP_015855076.1 NZ_CP059961:c1604070-1603852 [Pectobacterium brasiliense]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT169597 NZ_CP076619:c4743304-4743170 [Xanthomonas arboricola pv. corylina]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A250BG46

References