Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 87174..87814 Replicon chromosome
Accession NZ_CP059961
Organism Pectobacterium brasiliense strain IPO:4057 NAK:249

Toxin (Protein)


Gene name vagD Uniprot ID A0A7V8Q162
Locus tag H5A39_RS00430 Protein ID WP_039278477.1
Coordinates 87174..87590 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A086EF97
Locus tag H5A39_RS00435 Protein ID WP_039278475.1
Coordinates 87587..87814 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A39_RS00410 82759..83745 - 987 WP_040033638.1 quinone oxidoreductase -
H5A39_RS00415 83874..85280 + 1407 WP_010279223.1 replicative DNA helicase -
H5A39_RS00420 85322..86404 + 1083 WP_119872014.1 alanine racemase -
H5A39_RS00425 86397..87035 + 639 WP_039517591.1 hypothetical protein -
H5A39_RS00430 87174..87590 - 417 WP_039278477.1 type II toxin-antitoxin system VapC family toxin Toxin
H5A39_RS00435 87587..87814 - 228 WP_039278475.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H5A39_RS00440 88731..89210 + 480 WP_010295086.1 Lrp/AsnC family transcriptional regulator -
H5A39_RS00445 89461..90075 + 615 WP_119872013.1 YitT family protein -
H5A39_RS00450 90139..91332 + 1194 WP_119872012.1 aspartate/tyrosine/aromatic aminotransferase -
H5A39_RS00455 91416..91913 + 498 WP_039278469.1 M48 family metallopeptidase -
H5A39_RS00460 92038..92517 + 480 WP_014916572.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15274.80 Da        Isoelectric Point: 8.2931

>T169585 WP_039278477.1 NZ_CP059961:c87590-87174 [Pectobacterium brasiliense]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIELAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T169585 NZ_CP076604:124349-124636 [Acinetobacter schindleri]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAGCCATTGAA
GAAGAAGTTGATCAAGGTTTTGGAGAATCCTCGCATTCCCAAAAACAAGTTGTCAGGACATCCTAACCGCTACAAGATCA
AACTTCGTAGTATTGGTTATCGTCTGGTTTATGAAGTCGTTGATGATGAGGTAGTTGTCATCGTGATTGCTGTAGGCAGA
CGTGAAAACAATGCCGTCTATGATGATGCCAACTCTCGTCATTCATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8879.08 Da        Isoelectric Point: 4.8359

>AT169585 WP_039278475.1 NZ_CP059961:c87814-87587 [Pectobacterium brasiliense]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPVKPNWHSFLQEDRADADFMTERQDVVEEGRFKL

Download         Length: 228 bp

>AT169585 NZ_CP076604:124111-124359 [Acinetobacter schindleri]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTGGCAGG
CAAAGGCGAACCTGTCGCAATCCTCAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATCTGTATGAAACGATGA
TGGAACAACTAGAAGACCTGGAACTGAATAAGATTGCAGATGCTCGTGCGAATCAGAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8Q162

Antitoxin

Source ID Structure
AlphaFold DB A0A086EF97

References