Detailed information of TA system TA169580

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2091296..2091956
• Replicon: chromosome
• Accession: NZ_CP059960
• Organism: Pectobacterium brasiliense strain IPO:4060 NAK:251

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H5A37_RS09515
• Protein ID: WP_072061666.1
• Coordinates: 2091543..2091956 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1D7Z1Z6
• Locus tag: H5A37_RS09510
• Protein ID: WP_005971623.1
• Coordinates: 2091296..2091562 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5A37_RS09490	2087259..2088263	-	1005	WP_119870587.1	LacI family DNA-binding transcriptional regulator	-
H5A37_RS09495	2088318..2088926	-	609	WP_010279828.1	HD domain-containing protein	-
H5A37_RS09500	2089357..2090004	+	648	WP_010279833.1	hemolysin III family protein	-
H5A37_RS09505	2090059..2091060	-	1002	WP_010279836.1	tRNA-modifying protein YgfZ	-
H5A37_RS09510	2091296..2091562	+	267	WP_005971623.1	FAD assembly factor SdhE	Antitoxin
H5A37_RS09515	2091543..2091956	+	414	WP_072061666.1	protein YgfX	Toxin
H5A37_RS09520	2092025..2092960	+	936	WP_119870588.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
H5A37_RS09525	2093026..2093349	-	324	WP_119870589.1	hypothetical protein	-
H5A37_RS09530	2093378..2093896	-	519	WP_119870590.1	flavodoxin FldB	-
H5A37_RS09535	2094239..2094625	-	387	WP_048256533.1	acyl-CoA thioesterase	-
H5A37_RS09540	2094830..2096158	-	1329	WP_039282120.1	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16325.29 Da
• Isoelectric Point: 10.7911

>T169580 WP_072061666.1 NZ_CP059960:2091543-2091956 [Pectobacterium brasiliense]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGILLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Nucleotide

• Length: 414 bp

>T169580 NZ_CP059960:2091543-2091956 [Pectobacterium brasiliense]
GTGGCCCAGTGGCGATGTGACCTCCGCGTTTCCTGGCGCATGCAGCTGTTATCATTGGTTGTGCATGGCCTATTAGTATT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCATGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGCTGCTGAAGAATGGCATATTACTGTCATTGCAAGCGGTTAACGGTAAAGACAA
GCAACAGCTGTGGCTGGCATCGGACAGCATGGGTGATGACGAATGGCGTCACTTGCGTCAAATTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10507.94 Da
• Isoelectric Point: 5.1392

>AT169580 WP_005971623.1 NZ_CP059960:2091296-2091562 [Pectobacterium brasiliense]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT169580 NZ_CP059960:2091296-2091562 [Pectobacterium brasiliense]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCAATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGCACGTTTGTACGCTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGGAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1D7Z1Z6