Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1404066..1404601 Replicon chromosome
Accession NZ_CP059960
Organism Pectobacterium brasiliense strain IPO:4060 NAK:251

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag H5A37_RS06310 Protein ID WP_015842269.1
Coordinates 1404066..1404353 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag H5A37_RS06315 Protein ID WP_010281712.1
Coordinates 1404350..1404601 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A37_RS06285 1399378..1400106 - 729 WP_039498362.1 DUF1266 domain-containing protein -
H5A37_RS06290 1400279..1400839 + 561 Protein_1210 alkyl/aryl-sulfatase -
H5A37_RS06295 1400961..1401344 + 384 WP_014913665.1 TfoX/Sxy family protein -
H5A37_RS06300 1401625..1402467 + 843 WP_010281707.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
H5A37_RS06305 1402596..1403948 + 1353 WP_119871553.1 glutathione-disulfide reductase -
H5A37_RS06310 1404066..1404353 - 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A37_RS06315 1404350..1404601 - 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5A37_RS06320 1404856..1405761 + 906 WP_119871554.1 siderophore-interacting protein -
H5A37_RS06325 1405795..1406550 - 756 WP_119871555.1 thiol:disulfide interchange protein DsbG -
H5A37_RS06330 1406818..1407441 + 624 WP_119871556.1 LysE family translocator -
H5A37_RS06335 1407501..1408541 - 1041 WP_119871557.1 HipA domain-containing protein -
H5A37_RS06340 1408538..1408852 - 315 WP_039279922.1 HipA N-terminal domain-containing protein -
H5A37_RS06345 1408837..1409163 - 327 WP_039510297.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T169573 WP_015842269.1 NZ_CP059960:c1404353-1404066 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T169573 NZ_CP076595:c1622192-1621872 [Erwinia amylovora]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCTCCCGTGCAGGTGTGGCAGCAACTTTTAAC
GTATCTGCTGGAGCATCATTACGGCTTGACACTAAATGACACGCCATTCCATGACGACGCGGCCATTGAGGAGCATATCG
ACGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGTATCGACCGCAAAGGATTT
ACATGGCAGGAGCAGACGCCATTCCTGGCCGCCACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATATTTA
A

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT169573 WP_010281712.1 NZ_CP059960:c1404601-1404350 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT169573 NZ_CP076595:c1622552-1622229 [Erwinia amylovora]
ATGTCAATCACACTACCTCATGAATGGGGTCTACAAAGCGATATCACCCCACGATTTGGCGCGAGATTAGTTCAGGAAGG
CAATCGGCTGTATTACCTGGCTGACAGGGCTGGATTAACGGTGAGCTTTAGCCCGATACACCTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTGTAGAACAACTGGAAAATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACATCAGGTGACC
ATTCAACTTACGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCAACCCC
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References