Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2603079..2603704 Replicon chromosome
Accession NZ_CP059959
Organism Pectobacterium brasiliense strain IPO:4062 NAK:237

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag H5A40_RS11695 Protein ID WP_005976087.1
Coordinates 2603079..2603282 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag H5A40_RS11700 Protein ID WP_010282247.1
Coordinates 2603336..2603704 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A40_RS11665 2598412..2598750 + 339 WP_002208627.1 P-II family nitrogen regulator -
H5A40_RS11670 2598790..2600076 + 1287 WP_014914537.1 ammonium transporter AmtB -
H5A40_RS11675 2600216..2601079 - 864 WP_014914538.1 acyl-CoA thioesterase II -
H5A40_RS11680 2601292..2601873 + 582 WP_205590967.1 YbaY family lipoprotein -
H5A40_RS11685 2601893..2602213 - 321 WP_010282239.1 MGMT family protein -
H5A40_RS11695 2603079..2603282 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
H5A40_RS11700 2603336..2603704 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
H5A40_RS11705 2604302..2604445 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
H5A40_RS11710 2604463..2604711 - 249 WP_039274617.1 type B 50S ribosomal protein L31 -
H5A40_RS11715 2604945..2608073 - 3129 WP_205590968.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T169566 WP_005976087.1 NZ_CP059959:c2603282-2603079 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T169566 NZ_CP076594:c3117992-3117717 [Erwinia amylovora]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT169566 WP_010282247.1 NZ_CP059959:c2603704-2603336 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT169566 NZ_CP076594:c3118244-3117996 [Erwinia amylovora]
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References