Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2603079..2603704 | Replicon | chromosome |
Accession | NZ_CP059959 | ||
Organism | Pectobacterium brasiliense strain IPO:4062 NAK:237 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | C6DB72 |
Locus tag | H5A40_RS11695 | Protein ID | WP_005976087.1 |
Coordinates | 2603079..2603282 (-) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | Q6D809 |
Locus tag | H5A40_RS11700 | Protein ID | WP_010282247.1 |
Coordinates | 2603336..2603704 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5A40_RS11665 | 2598412..2598750 | + | 339 | WP_002208627.1 | P-II family nitrogen regulator | - |
H5A40_RS11670 | 2598790..2600076 | + | 1287 | WP_014914537.1 | ammonium transporter AmtB | - |
H5A40_RS11675 | 2600216..2601079 | - | 864 | WP_014914538.1 | acyl-CoA thioesterase II | - |
H5A40_RS11680 | 2601292..2601873 | + | 582 | WP_205590967.1 | YbaY family lipoprotein | - |
H5A40_RS11685 | 2601893..2602213 | - | 321 | WP_010282239.1 | MGMT family protein | - |
H5A40_RS11695 | 2603079..2603282 | - | 204 | WP_005976087.1 | hemolysin expression modulator Hha | Toxin |
H5A40_RS11700 | 2603336..2603704 | - | 369 | WP_010282247.1 | Hha toxicity modulator TomB | Antitoxin |
H5A40_RS11705 | 2604302..2604445 | - | 144 | WP_005976091.1 | type B 50S ribosomal protein L36 | - |
H5A40_RS11710 | 2604463..2604711 | - | 249 | WP_039274617.1 | type B 50S ribosomal protein L31 | - |
H5A40_RS11715 | 2604945..2608073 | - | 3129 | WP_205590968.1 | efflux RND transporter permease subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8145.52 Da Isoelectric Point: 8.9008
>T169566 WP_005976087.1 NZ_CP059959:c2603282-2603079 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR
Download Length: 204 bp
>T169566 NZ_CP076594:c3117992-3117717 [Erwinia amylovora]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14046.80 Da Isoelectric Point: 4.4787
>AT169566 WP_010282247.1 NZ_CP059959:c2603704-2603336 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT
Download Length: 369 bp
>AT169566 NZ_CP076594:c3118244-3117996 [Erwinia amylovora]
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D7Z3F0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086EI31 |