Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2104661..2105321 Replicon chromosome
Accession NZ_CP059959
Organism Pectobacterium brasiliense strain IPO:4062 NAK:237

Toxin (Protein)


Gene name cptA Uniprot ID A0A837DIN4
Locus tag H5A40_RS09595 Protein ID WP_039275532.1
Coordinates 2104908..2105321 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag H5A40_RS09590 Protein ID WP_005971623.1
Coordinates 2104661..2104927 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A40_RS09570 2100489..2101493 - 1005 WP_104213454.1 LacI family DNA-binding transcriptional regulator -
H5A40_RS09575 2101548..2102156 - 609 WP_014914174.1 HD domain-containing protein -
H5A40_RS09580 2102586..2103233 + 648 WP_010279833.1 hemolysin III family protein -
H5A40_RS09585 2103424..2104425 - 1002 WP_014914175.1 tRNA-modifying protein YgfZ -
H5A40_RS09590 2104661..2104927 + 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
H5A40_RS09595 2104908..2105321 + 414 WP_039275532.1 protein YgfX Toxin
H5A40_RS09600 2105390..2106325 + 936 WP_010301818.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
H5A40_RS09605 2106391..2106714 - 324 WP_014914177.1 hypothetical protein -
H5A40_RS09610 2106743..2107261 - 519 WP_039548256.1 flavodoxin FldB -
H5A40_RS09615 2107605..2107991 - 387 WP_039282122.1 thioesterase family protein -
H5A40_RS09620 2108196..2109524 - 1329 WP_039282120.1 MHS family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16311.26 Da        Isoelectric Point: 10.7911

>T169564 WP_039275532.1 NZ_CP059959:2104908-2105321 [Pectobacterium brasiliense]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T169564 NZ_CP076594:2505719-2505937 [Erwinia amylovora]
ATGACTGACAAACTTCTAACGAAAACTGACTACCTGATGCGCCTCAGGCGTTGTCGTTCAATCGATACACTTGAACGCGT
GATTGAAAAGAACAAGTACGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCTGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTCGCTGTCTGGAAGTTTGTCCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT169564 WP_005971623.1 NZ_CP059959:2104661-2104927 [Pectobacterium brasiliense]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT169564 NZ_CP076594:2505310-2505699 [Erwinia amylovora]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCATCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTTCAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACAATGAATTACAAAATCAAGCATATCGAAGACAGCGATCTGATAAGTCAAATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTACGGTGTCAACAATCTTGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCGTAATGAGCCAGATCCAGTCCAGCCATTCATTTAGCAGCCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837DIN4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References