Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1857820..1858403 Replicon chromosome
Accession NZ_CP059959
Organism Pectobacterium brasiliense strain IPO:4062 NAK:237

Toxin (Protein)


Gene name parE Uniprot ID A0A7V8QAI8
Locus tag H5A40_RS08435 Protein ID WP_012822278.1
Coordinates 1858098..1858403 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V8TMU0
Locus tag H5A40_RS08430 Protein ID WP_012822277.1
Coordinates 1857820..1858110 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A40_RS08410 1852954..1854216 - 1263 WP_039504938.1 L-rhamnose isomerase -
H5A40_RS08415 1854213..1855703 - 1491 WP_205592216.1 rhamnulokinase -
H5A40_RS08420 1856040..1856879 + 840 WP_014913998.1 HTH-type transcriptional activator RhaS -
H5A40_RS08425 1856904..1857758 + 855 WP_205592217.1 helix-turn-helix domain-containing protein -
H5A40_RS08430 1857820..1858110 + 291 WP_012822277.1 ribbon-helix-helix protein, CopG family Antitoxin
H5A40_RS08435 1858098..1858403 + 306 WP_012822278.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A40_RS08440 1858463..1860172 - 1710 WP_205592218.1 dipeptide ABC transporter ATP-binding protein -
H5A40_RS08445 1860169..1861035 - 867 WP_010285293.1 ABC transporter permease -
H5A40_RS08450 1861028..1861987 - 960 WP_039279295.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11634.48 Da        Isoelectric Point: 9.4590

>T169563 WP_012822278.1 NZ_CP059959:1858098-1858403 [Pectobacterium brasiliense]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTDRVVILTVKHQKEAGYQNP

Download         Length: 306 bp

>T169563 NZ_CP076594:c1750773-1750402 [Erwinia amylovora]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11097.16 Da        Isoelectric Point: 4.7845

>AT169563 WP_012822277.1 NZ_CP059959:1857820-1858110 [Pectobacterium brasiliense]
MADTPRQTTTLRIDQDIKERLKTLADDRHSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEEYQNTGEHITADETVTWL
ESWGSGHEQDAPACHK

Download         Length: 291 bp

>AT169563 NZ_CP076594:c1750991-1750770 [Erwinia amylovora]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8QAI8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8TMU0

References