Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1221215..1221750 Replicon chromosome
Accession NZ_CP059959
Organism Pectobacterium brasiliense strain IPO:4062 NAK:237

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag H5A40_RS05545 Protein ID WP_015842269.1
Coordinates 1221463..1221750 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag H5A40_RS05540 Protein ID WP_010281712.1
Coordinates 1221215..1221466 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A40_RS05515 1216848..1217360 - 513 WP_205592408.1 phenolic acid decarboxylase -
H5A40_RS05520 1217460..1218332 + 873 WP_205592063.1 LysR family transcriptional regulator -
H5A40_RS05525 1218376..1218999 - 624 WP_039510292.1 LysE family translocator -
H5A40_RS05530 1219266..1220021 + 756 WP_205592064.1 thiol:disulfide interchange protein DsbG -
H5A40_RS05535 1220055..1220960 - 906 WP_205592065.1 siderophore-interacting protein -
H5A40_RS05540 1221215..1221466 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5A40_RS05545 1221463..1221750 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A40_RS05550 1222151..1222576 + 426 WP_205592066.1 hypothetical protein -
H5A40_RS05555 1222644..1223561 + 918 WP_039284925.1 hypothetical protein -
H5A40_RS05560 1223578..1223922 + 345 WP_039284923.1 hypothetical protein -
H5A40_RS05565 1224148..1225058 - 911 Protein_1070 IS4 family transposase -
H5A40_RS05570 1225196..1226548 - 1353 WP_010296544.1 glutathione-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T169560 WP_015842269.1 NZ_CP059959:1221463-1221750 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T169560 NZ_CP076592:3754528-3754707 [Erwinia amylovora]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT169560 WP_010281712.1 NZ_CP059959:1221215-1221466 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT169560 NZ_CP076592:3754730-3755140 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References