Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 446729..447369 Replicon chromosome
Accession NZ_CP059959
Organism Pectobacterium brasiliense strain IPO:4062 NAK:237

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag H5A40_RS02065 Protein ID WP_052902920.1
Coordinates 446729..447145 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag H5A40_RS02070 Protein ID WP_205591870.1
Coordinates 447142..447369 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A40_RS02045 442119..443105 - 987 WP_040033638.1 quinone oxidoreductase -
H5A40_RS02050 443429..444835 + 1407 WP_010279223.1 replicative DNA helicase -
H5A40_RS02055 444877..445959 + 1083 WP_205591869.1 alanine racemase -
H5A40_RS02060 445952..446590 + 639 WP_039517591.1 hypothetical protein -
H5A40_RS02065 446729..447145 - 417 WP_052902920.1 type II toxin-antitoxin system VapC family toxin Toxin
H5A40_RS02070 447142..447369 - 228 WP_205591870.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H5A40_RS02075 448346..448825 + 480 WP_010279234.1 Lrp/AsnC family transcriptional regulator -
H5A40_RS02080 449076..449690 + 615 WP_014916569.1 YitT family protein -
H5A40_RS02085 449754..450947 + 1194 WP_039465897.1 aspartate/tyrosine/aromatic aminotransferase -
H5A40_RS02090 451031..451528 + 498 WP_039278469.1 M48 family metallopeptidase -
H5A40_RS02095 451653..452132 + 480 WP_014916572.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15302.86 Da        Isoelectric Point: 8.2931

>T169559 WP_052902920.1 NZ_CP059959:c447145-446729 [Pectobacterium brasiliense]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIELAAAGTPIGPNDTAIAGHAISVKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T169559 NZ_CP076592:3694913-3695284 [Erwinia amylovora]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8878.14 Da        Isoelectric Point: 5.8508

>AT169559 WP_205591870.1 NZ_CP059959:c447369-447142 [Pectobacterium brasiliense]
MRIVSVFKNGNNRAIRLPRDMDFEGVNKLEIVREGDTIMLRPVKPNWHSFLQEDRADADFMTERQDVVEEGRFKL

Download         Length: 228 bp

>AT169559 NZ_CP076592:3694695-3694916 [Erwinia amylovora]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References