Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2422017..2423605 Replicon chromosome
Accession NZ_CP059958
Organism Pectobacterium brasiliense strain IPO:4065 NAK:223

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H5A29_RS10725 Protein ID WP_119870763.1
Coordinates 2422286..2423605 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H5A29_RS10720 Protein ID WP_103943261.1
Coordinates 2422017..2422286 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A29_RS10690 2417055..2417714 + 660 WP_014917137.1 DUF799 domain-containing protein -
H5A29_RS10695 2417837..2419339 - 1503 WP_119870760.1 MFS transporter -
H5A29_RS10700 2419443..2419994 + 552 WP_119870761.1 TetR/AcrR family transcriptional regulator -
H5A29_RS10705 2420025..2420435 - 411 WP_094431545.1 helix-turn-helix transcriptional regulator -
H5A29_RS10710 2420578..2421429 + 852 WP_119870762.1 SDR family oxidoreductase -
H5A29_RS10715 2421558..2421824 + 267 Protein_2093 alpha/beta hydrolase -
H5A29_RS10720 2422017..2422286 + 270 WP_103943261.1 helix-turn-helix domain-containing protein Antitoxin
H5A29_RS10725 2422286..2423605 + 1320 WP_119870763.1 type II toxin-antitoxin system HipA family toxin Toxin
H5A29_RS10730 2423638..2425002 - 1365 WP_119870764.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
H5A29_RS10735 2425132..2426766 - 1635 WP_010281240.1 membrane protein insertase YidC -
H5A29_RS10740 2426769..2427026 - 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
H5A29_RS10745 2426990..2427349 - 360 WP_010281235.1 ribonuclease P protein component -
H5A29_RS10750 2427368..2427508 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49397.67 Da        Isoelectric Point: 6.6897

>T169552 WP_119870763.1 NZ_CP059958:2422286-2423605 [Pectobacterium brasiliense]
MAALDVYMNGYRVGILTKTGSGAHHFSYDTNWLGLLGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
TDSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDRWCLPLNVTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVYPERDRYRFMQTQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKVVGFARESMENILAEFAQTV
DTVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T169552 NZ_CP076591:c2001746-2001426 [Erwinia amylovora]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCTCCCGTGCAGGTGTGGCAGCAACTTTTAAC
GTATCTGCTGGAGCATCATTACGGCTTGACACTAAATGACACGCCATTCCATGACGACGCGGCCATTGAGGAGCATATCG
ACGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGTATCGACCGCAAAGGATTT
ACATGGCAGGAGCAGACGCCATTCCTGGCCGCCACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATATTTA
A

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.40 Da        Isoelectric Point: 9.7281

>AT169552 WP_103943261.1 NZ_CP059958:2422017-2422286 [Pectobacterium brasiliense]
MMKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEAS
VASSWKEEW

Download         Length: 270 bp

>AT169552 NZ_CP076591:c2002106-2001783 [Erwinia amylovora]
ATGTCAATCACACTACCTCATGAATGGGGTCTACAAAGCGATATCACCCCACGATTTGGCGCGAGATTAGTTCAGGAAGG
CAATCGGCTGTATTACCTGGCTGACAGGGCTGGATTAACGGTGAGCTTTAGCCCGATACACCTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTGTAGAACAACTGGAAAATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACATCAGGTGACC
ATTCAACTTACGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCAACCCC
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References