Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 566324..566859 Replicon chromosome
Accession NZ_CP059957
Organism Pectobacterium brasiliense strain IPO:4071 NAK:240

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag H5A30_RS02640 Protein ID WP_015842269.1
Coordinates 566572..566859 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag H5A30_RS02635 Protein ID WP_010281712.1
Coordinates 566324..566575 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A30_RS02605 561762..562088 + 327 WP_039510297.1 helix-turn-helix domain-containing protein -
H5A30_RS02610 562073..562387 + 315 WP_039279922.1 HipA N-terminal domain-containing protein -
H5A30_RS02615 562384..563424 + 1041 WP_119871557.1 HipA domain-containing protein -
H5A30_RS02620 563484..564107 - 624 WP_119871556.1 LysE family translocator -
H5A30_RS02625 564375..565130 + 756 WP_119871555.1 thiol:disulfide interchange protein DsbG -
H5A30_RS02630 565164..566069 - 906 WP_119871554.1 siderophore-interacting protein -
H5A30_RS02635 566324..566575 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5A30_RS02640 566572..566859 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A30_RS02645 566977..568329 - 1353 WP_119871553.1 glutathione-disulfide reductase -
H5A30_RS02650 568458..569300 - 843 WP_010281707.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
H5A30_RS02655 569581..569964 - 384 WP_014913665.1 TfoX/Sxy family protein -
H5A30_RS02660 570086..570646 - 561 Protein_515 alkyl/aryl-sulfatase -
H5A30_RS02665 570819..571547 + 729 WP_039498362.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T169529 WP_015842269.1 NZ_CP059957:566572-566859 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T169529 NZ_CP076553:c14247-13897 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT169529 WP_010281712.1 NZ_CP059957:566324-566575 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT169529 NZ_CP076553:c13892-13590 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References