Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3501568..3502193 Replicon chromosome
Accession NZ_CP059956
Organism Pectobacterium brasiliense strain IPO:4132 NAK:239

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag H5A38_RS15570 Protein ID WP_005976087.1
Coordinates 3501990..3502193 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag H5A38_RS15565 Protein ID WP_010282247.1
Coordinates 3501568..3501936 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A38_RS15550 3497201..3500329 + 3129 WP_205546137.1 efflux RND transporter permease subunit -
H5A38_RS15555 3500560..3500808 + 249 WP_039274617.1 type B 50S ribosomal protein L31 -
H5A38_RS15560 3500826..3500969 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
H5A38_RS15565 3501568..3501936 + 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
H5A38_RS15570 3501990..3502193 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
H5A38_RS15580 3503059..3503379 + 321 WP_010282239.1 MGMT family protein -
H5A38_RS15585 3503399..3503980 - 582 WP_119872105.1 YbaY family lipoprotein -
H5A38_RS15590 3504193..3505056 + 864 WP_014914538.1 acyl-CoA thioesterase II -
H5A38_RS15595 3505197..3506483 - 1287 WP_014914537.1 ammonium transporter AmtB -
H5A38_RS15600 3506523..3506861 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T169518 WP_005976087.1 NZ_CP059956:3501990-3502193 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T169518 NZ_CP076534:c840753-840619 [Xanthomonas arboricola pv. corylina]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT169518 WP_010282247.1 NZ_CP059956:3501568-3501936 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT169518 NZ_CP076534:c840988-840836 [Xanthomonas arboricola pv. corylina]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References