Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4399370..4399867 Replicon chromosome
Accession NZ_CP059947
Organism Escherichia coli strain 268.2

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag H5C70_RS21170 Protein ID WP_001173343.1
Coordinates 4399370..4399543 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag H5C70_RS21175 Protein ID WP_000398619.1
Coordinates 4399571..4399867 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C70_RS21160 4396040..4397497 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
H5C70_RS21165 4397734..4399251 + 1518 WP_001295074.1 lysine--tRNA ligase -
H5C70_RS21170 4399370..4399543 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
H5C70_RS21175 4399571..4399867 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
H5C70_RS21180 4400094..4400366 - 273 WP_000405647.1 N-acetyltransferase -
H5C70_RS21185 4400378..4400608 - 231 WP_000371698.1 (4Fe-4S)-binding protein -
H5C70_RS21190 4400789..4402420 + 1632 WP_001216461.1 sensor histidine kinase -
H5C70_RS21195 4402417..4403136 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - papX 4327310..4399867 72557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T169482 WP_001173343.1 NZ_CP059947:c4399543-4399370 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T169482 NZ_CP076517:c1988204-1987875 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGATATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCGGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTGACCCGAGGTTACGTTATTGGAAAAGAC
TACATTGCACTCTATCGTGTGGTCGAAAAAGAAGTGCGAGTTGGTCATCTCTTTGCGACTAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT169482 WP_000398619.1 NZ_CP059947:c4399867-4399571 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT169482 NZ_CP076517:c1988400-1988194 [Streptococcus suis]
ATGAACCAGTTGGATTTGACTGCTGGTTTTAACCTCTTTTTACAAAACATTGCTGTAAAAAATGAGTTGCCCATTCTGAC
AGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAACTTCAAAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCAG
GTCAAGGGATCAGCCTAGAAATCGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References