Detailed information of TA system TA169478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4101934..4102754
• Replicon: chromosome
• Accession: NZ_CP059947
• Organism: Escherichia coli strain 268.2

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: H5C70_RS19670
• Protein ID: WP_001054379.1
• Coordinates: 4101934..4102191 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H5C70_RS19675
• Protein ID: WP_000123957.1
• Coordinates: 4102203..4102754 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5C70_RS19650	4097565..4098671	+	1107	WP_001295733.1	N-acetylneuraminate epimerase	-
H5C70_RS19655	4098735..4099715	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
H5C70_RS19660	4100298..4101341	-	1044	WP_140427398.1	hypothetical protein	-
H5C70_RS19665	4101396..4101557	+	162	Protein_3847	GNAT family N-acetyltransferase	-
H5C70_RS19670	4101934..4102191	+	258	WP_001054379.1	YjhX family toxin	Toxin
H5C70_RS19675	4102203..4102754	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
H5C70_RS19680	4102806..4103552	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
H5C70_RS19685	4103680..4103940	+	261	WP_000077645.1	hypothetical protein	-
H5C70_RS19690	4104339..4105460	+	1122	WP_000010833.1	M42 family metallopeptidase	-
H5C70_RS19695	4105457..4105735	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H5C70_RS19700	4105747..4107060	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE	4089413..4110975	21562

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T169478 WP_001054379.1 NZ_CP059947:4101934-4102191 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T169478 NZ_CP076517:1010609-1010875 [Streptococcus suis]
ATGAAGACCAGTTATAAACTCGTACCAACCGGTCGTTTTATCAAACAGTTGAAAAAGCTGGACAAATTTACTCAAAAGCA
GATTACCAACTACCTGTCTAGTCATGTGACCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT169478 WP_000123957.1 NZ_CP059947:4102203-4102754 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT169478 NZ_CP076517:1010374-1010625 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCGCGTGTGGCTGACATTGCACTTGCAG
AATACGAGGCTGACTTGGCGAATGGCATTGAGCCGATAAGCTGGGAGGAAATGTTGGAAGATTTGGGGCTGACGGATGAA
GACCAGTTATAA

Structures

Toxin

• AlphaFold DB: B6I030