Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2449734..2450372 Replicon chromosome
Accession NZ_CP059947
Organism Escherichia coli strain 268.2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H5C70_RS11730 Protein ID WP_000813794.1
Coordinates 2450196..2450372 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H5C70_RS11725 Protein ID WP_001270286.1
Coordinates 2449734..2450150 (-) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C70_RS11700 2445051..2445704 - 654 Protein_2288 ABC transporter ATP-binding protein -
H5C70_RS11705 2445720..2446417 - 698 Protein_2289 IS1 family transposase -
H5C70_RS11710 2446473..2446841 - 369 Protein_2290 ABC transporter ATP-binding protein -
H5C70_RS11715 2446859..2448004 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
H5C70_RS11720 2448249..2449655 - 1407 WP_094315788.1 PLP-dependent aminotransferase family protein -
H5C70_RS11725 2449734..2450150 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H5C70_RS11730 2450196..2450372 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H5C70_RS11735 2450594..2450824 + 231 WP_000494244.1 YncJ family protein -
H5C70_RS11740 2450916..2452877 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H5C70_RS11745 2452950..2453486 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
H5C70_RS11750 2453539..2454753 + 1215 WP_001349372.1 BenE family transporter YdcO -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2454793..2456058 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin

(91-134)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T169472 WP_000813794.1 NZ_CP059947:c2450372-2450196 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T169472 NZ_CP076499:2504-2614 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT169472 WP_001270286.1 NZ_CP059947:c2450150-2449734 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT169472 NZ_CP076499:c2718-2654 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6HPB


Antitoxin

Source ID Structure

References