Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2449734..2450372 | Replicon | chromosome |
Accession | NZ_CP059947 | ||
Organism | Escherichia coli strain 268.2 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | S1F9G9 |
Locus tag | H5C70_RS11730 | Protein ID | WP_000813794.1 |
Coordinates | 2450196..2450372 (-) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | H5C70_RS11725 | Protein ID | WP_001270286.1 |
Coordinates | 2449734..2450150 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5C70_RS11700 | 2445051..2445704 | - | 654 | Protein_2288 | ABC transporter ATP-binding protein | - |
H5C70_RS11705 | 2445720..2446417 | - | 698 | Protein_2289 | IS1 family transposase | - |
H5C70_RS11710 | 2446473..2446841 | - | 369 | Protein_2290 | ABC transporter ATP-binding protein | - |
H5C70_RS11715 | 2446859..2448004 | - | 1146 | WP_000047456.1 | ABC transporter substrate-binding protein | - |
H5C70_RS11720 | 2448249..2449655 | - | 1407 | WP_094315788.1 | PLP-dependent aminotransferase family protein | - |
H5C70_RS11725 | 2449734..2450150 | - | 417 | WP_001270286.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
H5C70_RS11730 | 2450196..2450372 | - | 177 | WP_000813794.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
H5C70_RS11735 | 2450594..2450824 | + | 231 | WP_000494244.1 | YncJ family protein | - |
H5C70_RS11740 | 2450916..2452877 | - | 1962 | WP_001307191.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
H5C70_RS11745 | 2452950..2453486 | - | 537 | WP_000429141.1 | DNA-binding transcriptional regulator SutR | - |
H5C70_RS11750 | 2453539..2454753 | + | 1215 | WP_001349372.1 | BenE family transporter YdcO | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 2454793..2456058 | 1265 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6749.83 Da Isoelectric Point: 11.2298
>T169472 WP_000813794.1 NZ_CP059947:c2450372-2450196 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
Download Length: 177 bp
>T169472 NZ_CP076499:2504-2614 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15246.63 Da Isoelectric Point: 4.7386
>AT169472 WP_001270286.1 NZ_CP059947:c2450150-2449734 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
>AT169472 NZ_CP076499:c2718-2654 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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