Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4507136..4507774 Replicon chromosome
Accession NZ_CP059929
Organism Escherichia coli strain 162.2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H5C75_RS21900 Protein ID WP_000813794.1
Coordinates 4507136..4507312 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H5C75_RS21905 Protein ID WP_001270286.1
Coordinates 4507358..4507774 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C75_RS21880 (4502755) 4502755..4503969 - 1215 WP_001326689.1 BenE family transporter YdcO -
H5C75_RS21885 (4504022) 4504022..4504558 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H5C75_RS21890 (4504631) 4504631..4506592 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H5C75_RS21895 (4506684) 4506684..4506914 - 231 WP_097475362.1 DUF2554 family protein -
H5C75_RS21900 (4507136) 4507136..4507312 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H5C75_RS21905 (4507358) 4507358..4507774 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H5C75_RS21910 (4507853) 4507853..4509259 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
H5C75_RS21915 (4509504) 4509504..4510649 + 1146 WP_000047418.1 ABC transporter substrate-binding protein -
H5C75_RS21920 (4510667) 4510667..4511680 + 1014 WP_000220393.1 ABC transporter ATP-binding protein -
H5C75_RS21925 (4511681) 4511681..4512622 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T169454 WP_000813794.1 NZ_CP059929:4507136-4507312 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T169454 NZ_CP076493:2492619-2492714 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT169454 WP_001270286.1 NZ_CP059929:4507358-4507774 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT169454 NZ_CP076493:c2492813-2492749 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References