Detailed information of TA system TA169417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 37775..38151
• Replicon: plasmid p1
• Accession: NZ_CP059918
• Organism: Escherichia coli strain 64.1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: H5C78_RS25000
• Protein ID: WP_000969988.1
• Coordinates: 37775..37957 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: H5C78_RS25005
• Protein ID: WP_001324224.1
• Coordinates: 37954..38151 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5C78_RS24990	35774..36808	-	1035	WP_001190233.1	3-deoxy-7-phosphoheptulonate synthase	-
H5C78_RS24995	37368..37676	-	309	WP_000377483.1	hypothetical protein	-
H5C78_RS25000	37775..37957	-	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H5C78_RS25005	37954..38151	-	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
H5C78_RS25010	38833..40107	+	1275	WP_175067017.1	HlyD family secretion protein	-
H5C78_RS25015	40082..42196	+	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
H5C78_RS25020	42366..42677	-	312	WP_001259758.1	colicin V	-
H5C78_RS25025	42655..42891	-	237	WP_001323890.1	colicin V immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA	1..214538	214538

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T169417 WP_000969988.1 NZ_CP059918:c37957-37775 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T169417 NZ_CP076470:3820441-3820544 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT169417 WP_001324224.1 NZ_CP059918:c38151-37954 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT169417 NZ_CP076470:c3820582-3820311 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A075MDK3