Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4012338..4013170 Replicon chromosome
Accession NZ_CP059917
Organism Escherichia coli strain 64.1

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag H5C78_RS19255 Protein ID WP_000854753.1
Coordinates 4012796..4013170 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag H5C78_RS19250 Protein ID WP_001278232.1
Coordinates 4012338..4012706 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C78_RS19215 4008180..4008860 + 681 WP_001282921.1 WYL domain-containing protein -
H5C78_RS19220 4009008..4009685 + 678 WP_001097302.1 hypothetical protein -
H5C78_RS19225 4009691..4009924 + 234 WP_001278287.1 DUF905 family protein -
H5C78_RS19230 4010014..4010832 + 819 WP_001175148.1 DUF945 domain-containing protein -
H5C78_RS19235 4010914..4011393 + 480 WP_000860065.1 antirestriction protein -
H5C78_RS19240 4011409..4011885 + 477 WP_001186724.1 RadC family protein -
H5C78_RS19245 4011954..4012175 + 222 WP_001405861.1 DUF987 domain-containing protein -
H5C78_RS19250 4012338..4012706 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H5C78_RS19255 4012796..4013170 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
H5C78_RS19260 4013167..4013655 + 489 WP_000777541.1 hypothetical protein -
H5C78_RS19265 4013667..4013864 + 198 WP_000839281.1 DUF957 domain-containing protein -
H5C78_RS19270 4013961..4014530 + 570 WP_001290247.1 DUF4942 domain-containing protein -
H5C78_RS19275 4014810..4015346 - 537 WP_000942807.1 GspM family type II secretion system protein YghD -
H5C78_RS19280 4015348..4016526 - 1179 WP_000097200.1 type II secretion system protein GspL -
H5C78_RS19285 4016523..4017500 - 978 WP_000633196.1 type II secretion system minor pseudopilin GspK -
H5C78_RS19290 4017497..4018102 - 606 WP_001318033.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T169406 WP_000854753.1 NZ_CP059917:4012796-4013170 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T169406 NZ_CP076470:2051189-2051296 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT169406 WP_001278232.1 NZ_CP059917:4012338-4012706 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT169406 NZ_CP076470:c2051140-2051074 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References