Detailed information of TA system TA169382

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 600913..601711
• Replicon: chromosome
• Accession: NZ_CP059917
• Organism: Escherichia coli strain 64.1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H5C78_RS02825
• Protein ID: WP_021527178.1
• Coordinates: 601334..601711 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2G4AEZ5
• Locus tag: H5C78_RS02820
• Protein ID: WP_001285608.1
• Coordinates: 600913..601287 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5C78_RS02780	596637..597317	+	681	WP_001282921.1	WYL domain-containing protein	-
H5C78_RS02785	597465..598142	+	678	WP_021527176.1	hypothetical protein	-
H5C78_RS02790	598148..598381	+	234	WP_001278293.1	DUF905 family protein	-
H5C78_RS02795	598471..599289	+	819	WP_001175165.1	DUF945 domain-containing protein	-
H5C78_RS02800	599315..599455	-	141	WP_000997937.1	hypothetical protein	-
H5C78_RS02805	599555..600034	+	480	WP_000706980.1	antirestriction protein	-
H5C78_RS02810	600049..600525	+	477	WP_001186188.1	RadC family protein	-
H5C78_RS02815	600612..600833	+	222	WP_000692350.1	DUF987 domain-containing protein	-
H5C78_RS02820	600913..601287	+	375	WP_001285608.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
H5C78_RS02825	601334..601711	+	378	WP_021527178.1	TA system toxin CbtA family protein	Toxin
H5C78_RS02830	601708..602196	+	489	WP_000777664.1	hypothetical protein	-
H5C78_RS02835	602216..602413	+	198	WP_001327226.1	DUF957 domain-containing protein	-
H5C78_RS02840	602498..602644	+	147	WP_001290177.1	hypothetical protein	-
H5C78_RS02845	603597..605633	+	2037	WP_000417002.1	hypothetical protein	-
H5C78_RS02850	606032..606211	-	180	WP_001153034.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	iroB / fimB / fimE	570158..613942	43784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14027.93 Da
• Isoelectric Point: 7.9086

>T169382 WP_021527178.1 NZ_CP059917:601334-601711 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHSEAKQ

Nucleotide

• Length: 378 bp

>T169382 NZ_CP076453:332250-332618 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GCCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13610.37 Da
• Isoelectric Point: 5.5051

>AT169382 WP_001285608.1 NZ_CP059917:600913-601287 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Nucleotide

• Length: 375 bp

>AT169382 NZ_CP076453:332032-332253 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2G4AEZ5