Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 187253..187778 | Replicon | plasmid p1 |
| Accession | NZ_CP059908 | ||
| Organism | Escherichia coli strain 181.1 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | V0SSI5 |
| Locus tag | H5C80_RS26145 | Protein ID | WP_001159868.1 |
| Coordinates | 187473..187778 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | S1PPD8 |
| Locus tag | H5C80_RS26140 | Protein ID | WP_000813634.1 |
| Coordinates | 187253..187471 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5C80_RS26110 | 182330..182677 | + | 348 | WP_000142449.1 | hypothetical protein | - |
| H5C80_RS26115 | 182697..183287 | - | 591 | WP_000194553.1 | hypothetical protein | - |
| H5C80_RS26120 | 183287..183544 | - | 258 | WP_000371889.1 | hypothetical protein | - |
| H5C80_RS26125 | 183872..184975 | + | 1104 | WP_001127573.1 | nucleotide-binding protein | - |
| H5C80_RS26130 | 185005..186135 | + | 1131 | WP_000542418.1 | DUF4238 domain-containing protein | - |
| H5C80_RS26135 | 186135..186425 | + | 291 | WP_001229374.1 | hypothetical protein | - |
| H5C80_RS26140 | 187253..187471 | + | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| H5C80_RS26145 | 187473..187778 | + | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| H5C80_RS26150 | 187779..188585 | + | 807 | WP_001593069.1 | site-specific integrase | - |
| H5C80_RS26155 | 188765..189409 | + | 645 | WP_001144036.1 | ParA family protein | - |
| H5C80_RS26160 | 189496..189804 | + | 309 | WP_000030198.1 | hypothetical protein | - |
| H5C80_RS26165 | 190017..190714 | - | 698 | Protein_205 | IS1 family transposase | - |
| H5C80_RS26170 | 190770..191132 | + | 363 | Protein_206 | recombinase | - |
| H5C80_RS26175 | 191125..191541 | + | 417 | WP_001278813.1 | plasmid partitioning/stability family protein | - |
| H5C80_RS26180 | 191543..192056 | - | 514 | Protein_208 | DUF4113 domain-containing protein | - |
| H5C80_RS26185 | 192117..192221 | - | 105 | Protein_209 | AAA family ATPase | - |
| H5C80_RS26190 | 192223..192546 | - | 324 | Protein_210 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucB / iucA | 1..193291 | 193291 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11706.51 Da Isoelectric Point: 6.4674
>T169378 WP_001159868.1 NZ_CP059908:187473-187778 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T169378 NZ_CP076449:2084933-2085184 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8372.34 Da Isoelectric Point: 4.7405
>AT169378 WP_000813634.1 NZ_CP059908:187253-187471 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT169378 NZ_CP076449:2085181-2085435 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|