Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 98363..98898 Replicon plasmid p1
Accession NZ_CP059908
Organism Escherichia coli strain 181.1

Toxin (Protein)


Gene name relE Uniprot ID V0VJJ7
Locus tag H5C80_RS25620 Protein ID WP_000222760.1
Coordinates 98363..98650 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag H5C80_RS25625 Protein ID WP_001132900.1
Coordinates 98647..98898 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C80_RS25595 93946..95167 - 1222 Protein_91 ISL3 family transposase -
H5C80_RS25600 95267..95631 + 365 Protein_92 IS1 family transposase -
H5C80_RS25605 95686..96465 - 780 WP_001297096.1 IS21-like element IS100kyp family helper ATPase IstB -
H5C80_RS25610 96465..97487 - 1023 WP_000255946.1 IS21-like element IS100 family transposase -
H5C80_RS25615 97576..97923 + 348 Protein_95 IS1-like element IS1A family transposase -
H5C80_RS25620 98363..98650 - 288 WP_000222760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5C80_RS25625 98647..98898 - 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5C80_RS25630 99862..100719 - 858 WP_000774297.1 incFII family plasmid replication initiator RepA -
H5C80_RS25635 100712..101194 - 483 WP_001273588.1 hypothetical protein -
H5C80_RS25640 101187..101261 - 75 WP_001442103.1 RepA leader peptide Tap -
H5C80_RS25645 101493..101750 - 258 WP_000083845.1 replication regulatory protein RepA -
H5C80_RS25650 102034..102240 - 207 WP_001351576.1 type I toxin-antitoxin system Hok family toxin -
- 102227..102288 + 62 NuclAT_1 - -
- 102227..102288 + 62 NuclAT_1 - -
- 102227..102288 + 62 NuclAT_1 - -
- 102227..102288 + 62 NuclAT_1 - -
H5C80_RS25655 102544..102618 - 75 Protein_103 endonuclease -
H5C80_RS25660 102864..103076 - 213 WP_001299730.1 ANR family transcriptional regulator -
H5C80_RS25665 103212..103772 - 561 WP_000139315.1 fertility inhibition protein FinO -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucB / iucA 1..193291 193291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11105.15 Da        Isoelectric Point: 10.5832

>T169368 WP_000222760.1 NZ_CP059908:c98650-98363 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T169368 NZ_CP076445:c1328759-1328013 [Bacillus subtilis subsp. subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTAGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAGCCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT169368 WP_001132900.1 NZ_CP059908:c98898-98647 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT169368 NZ_CP076445:c1328013-1327843 [Bacillus subtilis subsp. subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0VJJ7


Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References