Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2230278..2230903 Replicon chromosome
Accession NZ_CP059907
Organism Escherichia coli strain 181.1

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag H5C80_RS10885 Protein ID WP_000911329.1
Coordinates 2230505..2230903 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H5C80_RS10880 Protein ID WP_000450524.1
Coordinates 2230278..2230505 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C80_RS10855 2226078..2226548 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H5C80_RS10860 2226548..2227120 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H5C80_RS10865 2227266..2228144 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H5C80_RS10870 2228161..2229195 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H5C80_RS10875 2229408..2230121 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H5C80_RS10880 2230278..2230505 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H5C80_RS10885 2230505..2230903 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
H5C80_RS10890 2231050..2231913 + 864 WP_001267498.1 neutral zinc metallopeptidase -
H5C80_RS10895 2231928..2233943 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
H5C80_RS10900 2234017..2234715 + 699 WP_000679819.1 esterase -
H5C80_RS10905 2234796..2234996 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T169345 WP_000911329.1 NZ_CP059907:2230505-2230903 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T169345 NZ_CP076406:c1697958-1697773 [Providencia rettgeri]
GTGCAAAGTTCGGAACTGATAAACATACTGCAAAAAAACGGTTGGAAACTTGAAAGAATAAAAGGAAGTCACCATCAGTT
TTCCCACCCACATTTTTCAATTGTAATTACTGTTCCGCATCCACAAAAAGATTTAAAGATAGGCACACTAAATCACATTT
TGAAGGCTGCGAAACTAAAACATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT169345 WP_000450524.1 NZ_CP059907:2230278-2230505 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT169345 NZ_CP076406:c1697723-1697310 [Providencia rettgeri]
ATGCTTTATACCGCCTTTATTGAAATTGATAATGATGGCAGCGCAAGTGGCTGGTTTCCTGATATTGAAGGATGTACATT
CGCGGGCAGCAATATAGAAGAGGCTTACGCAGAAGCAAAATCAGCAATTGATGCTCATTTTGAATTATTGAGTGAAAAAG
GCTTTGAGATCCCATTATCGAAATCTCAGCAAACGCTATTGAACCCAATACAACCTGAATATGCGCATGGGATATGGTTA
TTTGTGGATGTCGATATGGATAAATACGATGGCCGTACTGAGCGTATTAATATCACCTTGCCGCATCGTTTATTACATCG
TATTGATGCTTTAGTGAAGGTTAATCCTGAATATGGTAGCCGTAGTGGTTTTATTGCTGCTGCAGCTCGTAAAGAATTAA
AAAAAACCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References