Detailed information of TA system TA169327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2378122..2378780
• Replicon: chromosome
• Accession: NZ_CP059901
• Organism: Mumia sp. ZJ1417

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H4N58_RS11615
• Protein ID: WP_167003237.1
• Coordinates: 2378352..2378780 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H4N58_RS11610
• Protein ID: WP_167003234.1
• Coordinates: 2378122..2378355 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4N58_RS11585	2373406..2373561	+	156	WP_167003224.1	hypothetical protein	-
H4N58_RS11590	2373588..2374337	-	750	WP_167250636.1	hypothetical protein	-
H4N58_RS11595	2374347..2375777	-	1431	WP_167003228.1	MFS transporter	-
H4N58_RS11600	2375893..2376996	-	1104	WP_167003230.1	NAD(P)H-binding protein	-
H4N58_RS11605	2377138..2378103	+	966	WP_167250634.1	hypothetical protein	-
H4N58_RS11610	2378122..2378355	+	234	WP_167003234.1	ribbon-helix-helix domain-containing protein	Antitoxin
H4N58_RS11615	2378352..2378780	+	429	WP_167003237.1	PIN domain-containing protein	Toxin
H4N58_RS11620	2378888..2381971	+	3084	WP_167250632.1	Ig-like domain repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15826.01 Da
• Isoelectric Point: 6.8382

>T169327 WP_167003237.1 NZ_CP059901:2378352-2378780 [Mumia sp. ZJ1417]
VRALLDVNVLLALFDRDHADHARARDWLTAEITQGWASCPLTQNGFVRVVGQPQYPSPVPVAQAIQMLARACSTEHHEFW
PSDRSLLDETFVDPRRIHGPRQVTDLYLLATAVAHRGRFVTFDRAIPVSAVPGATNDHLVVL

Nucleotide

• Length: 429 bp

>T169327 NZ_CP076404:2724144-2724473 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8535.56 Da
• Isoelectric Point: 4.6558

>AT169327 WP_167003234.1 NZ_CP059901:2378122-2378355 [Mumia sp. ZJ1417]
VRTTLDIDDDVLRAVKERARREGRSAGAVVSDLVRESLTRSVDMKPDEGFFGFSPLPHRGPVVSNALVDELREEIGE

Nucleotide

• Length: 234 bp

>AT169327 NZ_CP076404:2723806-2724123 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA