Detailed information of TA system TA169326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 658856..659394
• Replicon: chromosome
• Accession: NZ_CP059901
• Organism: Mumia sp. ZJ1417

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: H4N58_RS03110
• Protein ID: WP_167001488.1
• Coordinates: 659092..659394 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: H4N58_RS03105
• Protein ID: WP_167001487.1
• Coordinates: 658856..659092 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4N58_RS03095	656780..657826	-	1047	WP_167001486.1	ornithine cyclodeaminase	-
H4N58_RS03100	657823..658632	-	810	WP_182397175.1	amidinotransferase	-
H4N58_RS03105	658856..659092	+	237	WP_167001487.1	ribbon-helix-helix protein, CopG family	Antitoxin
H4N58_RS03110	659092..659394	+	303	WP_167001488.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
H4N58_RS03115	659767..660492	-	726	WP_167001489.1	ABC transporter ATP-binding protein	-
H4N58_RS03120	660489..661262	-	774	WP_167001490.1	ABC transporter ATP-binding protein	-
H4N58_RS03125	661249..663198	-	1950	WP_167249066.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10877.58 Da
• Isoelectric Point: 5.6546

>T169326 WP_167001488.1 NZ_CP059901:659092-659394 [Mumia sp. ZJ1417]
MRPIHMARLDKARPVLILTREAVRPYLTRVTVAPITSTIRGLSTEVEVGPVNGLDHVSVVSCDNIVTVPVASVGRQLGFL
LDSQEAELADAVRAAFDLDW

Nucleotide

• Length: 303 bp

>T169326 NZ_CP076404:2712609-2713682 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8689.76 Da
• Isoelectric Point: 4.4247

>AT169326 WP_167001487.1 NZ_CP059901:658856-659092 [Mumia sp. ZJ1417]
MSTQIAVRLDEELVEFVDALVRRGEASSRAAVVARALERERRRKTAERDAAILAAARTDADMDDLAEFASRLPMDDID

Nucleotide

• Length: 237 bp

>AT169326 NZ_CP076404:2713675-2714046 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA