Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 158673..159199 Replicon chromosome
Accession NZ_CP059901
Organism Mumia sp. ZJ1417

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H4N58_RS00760 Protein ID WP_167249479.1
Coordinates 158673..158999 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H4N58_RS00765 Protein ID WP_167249477.1
Coordinates 158996..159199 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4N58_RS00745 153909..155354 - 1446 WP_167000963.1 gamma-aminobutyraldehyde dehydrogenase -
H4N58_RS00750 155411..157078 - 1668 WP_167249483.1 APC family permease -
H4N58_RS00755 157082..158662 + 1581 WP_167249481.1 PucR family transcriptional regulator -
H4N58_RS00760 158673..158999 - 327 WP_167249479.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H4N58_RS00765 158996..159199 - 204 WP_167249477.1 DUF3018 family protein Antitoxin
H4N58_RS00770 159255..159740 - 486 WP_167249475.1 SRPBCC domain-containing protein -
H4N58_RS00775 159770..160135 - 366 WP_167249473.1 VOC family protein -
H4N58_RS00780 160202..161068 + 867 WP_167000974.1 alpha/beta hydrolase -
H4N58_RS00785 161137..161319 + 183 WP_167000976.1 alpha/beta hydrolase -
H4N58_RS00790 161451..161648 - 198 WP_167000978.1 ribbon-helix-helix protein, CopG family -
H4N58_RS00795 161767..162330 - 564 WP_167249471.1 dihydrofolate reductase family protein -
H4N58_RS00800 162471..163325 + 855 WP_167000982.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-101)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11606.57 Da        Isoelectric Point: 10.7752

>T169324 WP_167249479.1 NZ_CP059901:c158999-158673 [Mumia sp. ZJ1417]
VNRGELWAVAGGTYASKPRPVLILQEDLFDATESVTVVPLTTAVVDAPLIRIPVPATRTTGIDRPSFAMVDKITTVRRSN
VGARIGRLPTSLLVDIERAALLFLGLAR

Download         Length: 327 bp

>T169324 NZ_CP076404:c2047961-2047707 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 8125.89 Da        Isoelectric Point: 5.7169

>AT169324 WP_167249477.1 NZ_CP059901:c159199-158996 [Mumia sp. ZJ1417]
MSVRDRVAEHRRRMRERGYRPIQVWVPDVRTEQFRDEAHRQAAALARADRRADDQDFVDEISDSWDE

Download         Length: 204 bp

>AT169324 NZ_CP076404:c2048209-2047958 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References